Exploring MRI as a Predictor of Surgical Fitness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether Magnetic Resonance Imaging (MRI) can serve as an alternative to Cardiopulmonary Exercise Testing (CPET) for assessing surgical fitness in patients with gastric, oesophageal, or pancreatic cancer. CPET is a demanding exercise test that measures a patient's maximum oxygen consumption and anaerobic threshold, which are critical for determining their ability to tolerate surgery. The study aims to evaluate the effectiveness of MRI in predicting surgical readiness, particularly for patients who may not be able to undergo traditional exercise testing due to physical limitations. By comparing MRI results with CPET outcomes, the research seeks to identify a less physically taxing method for evaluating surgical candidates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Inclusion criteria for patients (cohort 1)

* Patients diagnosed oesophageal/gastric or pancreatic cancer.
* Patients who have or a under consideration for a CPET investigation.
* Aged ≥ 18.
* Existing UHNM Patient.
* Willing and able to give fully informed consent.
* Willing and able to comply with the study procedures.

Inclusion criteria for staff volunteers (cohort 2)

* Aged ≥ 18 years.
* Willing and able to give fully informed consent.
* Willing and able to comply with the study procedures.
* UHNM member of staff.

Exclusion Criteria:

Exclusion criteria for patients (cohort 1)

* Patients with contraindications to MRI due to safety at 3T.
* Patients with metalwork within the imaging field of view (e.g., knee replacement).
* Claustrophobic patients.
* Patients outside of stated age range to ensure informed consent.
* Patients not referred for CPET investigations.
* Patients that are pregnant.
* Patients that are unable to communicate in English.
* Patients lacking the capacity and capability to give fully informed consent.
* Patients participating in any other interventional studies with a contraindication to their participation.
* Patients for whom the addition of an MRS scan would delay any part of their standard treatment pathway.
* History of diabetes.

Exclusion criteria for staff volunteers (cohort 2)

* Volunteers with contraindications to MRI due to safety at 3T.
* Volunteers with metalwork within the imaging field of view (e.g., knee replacement).
* Claustrophobic volunteers.
* Volunteers outside of stated age range to ensure informed consent.
* Volunteers that are pregnant.
* Volunteers that are unable to communicate in English.
* Volunteers lacking the capacity and capability to give fully informed consent.
* Volunteers participating in any other interventional studies with a contraindication to their participation.
* Known or suspected medical conditions pertinent to the area being scanned.
* History of diabetes.

Where it's running

• University Hospitals of North Midlands NHS Trust
  Stoke-on-Trent, United Kingdom Recruiting

Study contacts

• Study coordinator: Aviva Ogbolosingha
• Email: aviva.ogbolosingha@uhnm.nhs.uk
• Phone: 01782 675380

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.