Exploring microRNA 410 and BIRC7 pathways in women with recurrent miscarriages

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the role of microRNA 410 and BIRC7 pathways in women experiencing recurrent spontaneous abortion (RSA), defined as two or three consecutive miscarriages before 24 weeks of gestation. The research aims to understand the complex etiology of RSA, which may include genetic, anatomical, and immune factors, particularly focusing on the involvement of microRNA in trophoblast function. By analyzing the expression of miR-410-5p and its interaction with integrin alpha-6, the study seeks to uncover potential mechanisms underlying unexplained recurrent miscarriages. The findings could provide insights into new therapeutic targets for improving pregnancy outcomes in affected women.

Why it matters

Who can join: the full rules

Inclusion Criteria: maternal age is between 20 to 30 years and Gestational age before abortion less than 24 weeks.

Female with unexplained two or three consecutive or discontinuous miscarriages with the same sexual partner

Exclusion Criteria:

1. Female with one miscarriage
2. Female with explained causes of miscarriage
3. Female with cancer
4. Female with chronic illness.
5. Pregnant women above 30

Where it's running

• Medical Bochemistry Department
  Assiut, Assuit, Egypt Recruiting

Study contacts

• Study coordinator: Dr.Nesma Gamal
• Email: nesmagamal1@yahoo.com
• Phone: 1115191414

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.