Exploring microRNA 410 and BIRC7 pathways in women with recurrent miscarriages
Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage
This study is trying to understand how certain genetic factors might play a role in women who have multiple miscarriages, to help find new ways to improve their chances of having a successful pregnancy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 86 (estimated) |
| Ages | 20 Years to 30 Years |
| Sex | Female |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Assiut, Assuit) |
| Trial ID | NCT05658445 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of microRNA 410 and BIRC7 pathways in women experiencing recurrent spontaneous abortion (RSA), defined as two or three consecutive miscarriages before 24 weeks of gestation. The research aims to understand the complex etiology of RSA, which may include genetic, anatomical, and immune factors, particularly focusing on the involvement of microRNA in trophoblast function. By analyzing the expression of miR-410-5p and its interaction with integrin alpha-6, the study seeks to uncover potential mechanisms underlying unexplained recurrent miscarriages. The findings could provide insights into new therapeutic targets for improving pregnancy outcomes in affected women.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 20 to 30 who have experienced two or three consecutive miscarriages with the same partner and have no known causes for their miscarriages.
Not a fit: Patients who have had only one miscarriage, those with known causes of miscarriage, or those with chronic illnesses or cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of recurrent miscarriages, potentially enhancing pregnancy success rates for affected women.
How similar studies have performed: While the role of microRNAs in reproductive health is an emerging field, this specific investigation into microRNA 410 and BIRC7 pathways in RSA is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: maternal age is between 20 to 30 years and Gestational age before abortion less than 24 weeks. Female with unexplained two or three consecutive or discontinuous miscarriages with the same sexual partner Exclusion Criteria: 1. Female with one miscarriage 2. Female with explained causes of miscarriage 3. Female with cancer 4. Female with chronic illness. 5. Pregnant women above 30
Where this trial is running
Assiut, Assuit
- Medical Bochemistry Department — Assiut, Assuit, Egypt (Recruiting)
Study contacts
- Study coordinator: Dr.Nesma Gamal
- Email: nesmagamal1@yahoo.com
- Phone: 1115191414
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.