Exploring Metronomic Capecitabine for Advanced Hypopharyngeal Cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the effectiveness of metronomic capecitabine as an adjuvant therapy in improving disease-free survival for patients with locoregionally advanced hypopharyngeal carcinoma. Participants will have completed standard treatments such as chemoradiotherapy or surgery and will be evaluated for their eligibility based on specific clinical criteria. The treatment involves administering capecitabine in a metronomic dosing schedule to assess its impact on patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Age between 18 and 65 years old. 2. Histologically confirmed hypopharyngeal carcinoma, staged as IV (T4N0-1M0，anyTN2-3M0) (as defined by the 8th AJCC edition), Complete the recommended standard treatment (curative chemoradiotherapy, or radical surgery + postoperative chemo/radiotherapy ).

  3\. No clinical evidence of persistent locoregional disease or distant metastases after definitive chemoradiotherapy.

  4\. Within 8 weeks after completion of the last radiation dose. 5. Performance status of ECOG grade 0 or 1. 6. Adequate hematologic (neutrophil count \> 1.5×10\^9/L, hemoglobin \> 90g/L and platelet count \> 100×10\^9 /L), hepatic (alanine aminotransferase, aspartate aminotransferase ≤ 1.5×ULN, bilirubin ≤ 1.5×ULN, alkaline phosphatase \< 2.5×ULN) and renal function (creatinine clearance \> 50 ml/min).

  7\. Patients must be appraised of the investigational nature of the study and provide written informed consent.

Exclusion Criteria:

* 1.Patients who were known to be intolerable or allergic to capecitabine. 2. Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer.

  3\. Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control).

  4\. With esophagus cancer. 5. Pregnancy or lactation. 6. Other conditions that are not eligible for enrollment.

Where it's running

• Eye & ENT Hospital, Fudan University
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Lei Tao
• Email: doctortaolei@163.com
• Phone: +86-13916944810

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Neoadjuvant finotonlimab plus TP chemotherapy for SMARCB1-deficient sinonasal cancer

  This study tests whether giving finotonlimab with the TP chemotherapy regimen before surgery can shrink locally advanced SMARCB1-deficient sinonasal tumors in adults.

  Recruiting Phase 2 Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07927465

• Intelligent case management for microtia care from diagnosis through rehabilitation

  This trial tests a mobile, intelligent case-management platform to provide continuous, personalized nursing and health guidance for people with congenital microtia undergoing ear reconstruction.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai · NCT07846345

• Becotatug Vedotin plus PD-1 inhibitor for locally recurrent nasopharyngeal carcinoma

  This study tests whether adding becotatug vedotin to a PD-1 inhibitor helps people with locally recurrent nasopharyngeal cancer.

  Recruiting Phase 2 Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07781358

• Customized bifocal plus defocus lenses to slow myopic shift after congenital cataract surgery

  This study tests whether individually tailored bifocal plus defocus glasses can slow myopic progression in children aged 4–12 who had bilateral congenital cataract surgery.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07778797

• Effect of Dry Eye Treatment on Corneal Astigmatism Measurements

  This study tests whether short-term treatment for dry eye changes how consistently three devices measure corneal astigmatism in people preparing for cataract surgery.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07657858

• Surgery Plus Postoperative Radiotherapy for T4 Sinonasal Adenoid Cystic Carcinoma

  This study tests how well patients with T4 sinonasal adenoid cystic carcinoma tolerate the standard treatment of surgery followed by postoperative radiotherapy and what their 3-year progression-free survival looks like.

  Recruiting Eye & ENT Hospital of Fudan University · Harbin, Heilongjiang and 5 other locations · NCT07652489

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.