Exploring metabolic changes in patients with mild ARDS
NMR - Based Metabolomics Approach to Improve Clinical Management in Patients With Respiratory Failure
This study looks at the changes in blood chemistry of adults with mild acute respiratory distress syndrome (ARDS) to better understand how the condition develops and progresses.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Sanjay Gandhi Postgraduate Institute of Medical Sciences Government |
| Locations | 1 site (Lucknow, Uttar Pradesh) |
| Trial ID | NCT06036056 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the metabolic profiles of adult patients diagnosed with mild acute respiratory distress syndrome (ARDS) using NMR-based metabolomics. Participants will have blood samples collected within 72 hours of diagnosis and subsequently every 72 hours until recovery or discharge. The study will also include age-matched healthy controls for comparative analysis. By analyzing these metabolic changes, the research seeks to enhance understanding of the pathogenesis and progression of ARDS.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill adult patients aged 18 to 65 with mild ARDS onset within the last 72 hours.
Not a fit: Patients who are expected to survive less than 72 hours or those outside the age range of 18 to 65 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the identification of specific biomarkers for ARDS, improving diagnosis and treatment strategies.
How similar studies have performed: While the approach of using NMR-based metabolomics is relatively novel, similar studies have shown promise in identifying metabolic changes in other critical conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Critically ill adult patients having mild ARDS with onset less than 72 hours Exclusion Criteria: * Age less than 18 years or more than 65 years * Expected survival \<72 hours * Refusal from family member
Where this trial is running
Lucknow, Uttar Pradesh
- Centre of Biomedical Research — Lucknow, Uttar Pradesh, India (Recruiting)
Study contacts
- Principal investigator: Neeraj Sinha, M.Sc., Ph.D. — Centre of Biomedical Research
- Study coordinator: Mohan Gurjar, MD, PDCC
- Email: m.gurjar@rediffmail.com
- Phone: +91-522-249-5403
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.