Exploring Mechanical Stimulation for Ovarian Follicle Activation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the potential role of mechanical stimulation, specifically ovarian puncture, in activating dormant ovarian follicles in women with premature ovarian failure (POI). The study aims to understand how this technique, combined with hormonal assessments and transvaginal ultrasound, may improve fertility outcomes for women under 40 who have documented primary ovarian insufficiency. By examining the effects of mild local ovarian injury, the researchers hope to identify new approaches to enhance ovarian function and fertility in this challenging patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed and dated informed consent
* Women 40 years of age and younger with documented primary ovarian insufficiency (12).
* Normal Karyotype
* BMI \</= 35 kg/m2
* Oligo/amenorrhea for at least 4 months
* FSH \> 25 IU/mL
* AMH \</= 0,1 ng/ml
* No evidence of follicles \> 4mm
* Must have two ovaries of approximately equal volume.
* Willingness to undergo further fertility treatment, including IVF if there is evidence of response
* A transvaginal scan including Doppler for arteria ovarica will be performed previously to the surgical procedure.

Exclusion Criteria:

* Premature ovarian failure due to a genetic origin, such as Turner's Syndrome or chromosomal abnormality.
* Oncological diseases (specially, skeletal system and blood).
* Autoimmune diseases, for example, lupus erythematosus, etc.
* Previous treatments including radiotherapy or chemotherapy.
* Other conditions not suitable for surgical procedures and/or anesthesia.
* Anticoagulant or antiaggregant treatment.
* Acute and chronic infectious diseases.
* Active substance abuse or dependence.
* Major Mental health disorder.

Where it's running

• ART Fertility Clinics LLC
  Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates Recruiting

Study contacts

• Principal investigator: Laura Melado, PhD — ART Fertility Clinics LLC
• Study coordinator: barbara Lawrenz, PhD
• Email: jonalyn.edades@artfertilityclinics.com
• Phone: +97126528000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.