Exploring inflammation and coagulation factors to predict cerebral edema after subarachnoid hemorrhage
Inflammation and Coagulation Factors in Cerebrospinal Fluid for Predicting Persistent Cerebral Edema After Subarachnoid Hemorrhage
This study is testing if certain inflammation and blood clotting markers in the fluid around the brain can help predict if patients with subarachnoid hemorrhage will develop lasting swelling in the brain.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06009016 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of inflammation and coagulation factors present in cerebrospinal fluid to predict the occurrence of persistent cerebral edema following subarachnoid hemorrhage (SAH). Patients with a modified Fisher Scale of 3-4 and a confirmed diagnosis of SAH will be monitored for these factors. The study aims to identify potential biomarkers that could help in assessing the risk of cerebral edema in affected patients. By analyzing the levels of these factors, the research seeks to improve patient outcomes through better prediction and management strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are patients who have been admitted with subarachnoid hemorrhage and have a modified Fisher Scale score of 3-4.
Not a fit: Patients with angiogram-negative findings, a history of trauma or previous brain injury, or serious comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prediction and management of cerebral edema in patients after subarachnoid hemorrhage.
How similar studies have performed: While there is ongoing research in this area, the specific approach of using inflammation and coagulation factors in cerebrospinal fluid for predicting cerebral edema after SAH is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subarachnoid hemorrhage patients admitted to our neurosurgery department with modified Fisher Scale 3-4, with a confirmed radiographic diagnosis. Exclusion Criteria: * Angiogram-negative patients, patients with a history of trauma or previous brain injury (stroke, hemorrhage, surgery et al. which left associated chronic changes on CT), arteriovenous malformation, radiological data lost, accompany with serious comorbidities before subarachnoid hemorrhage onset (such as coagulation defects, uncontrollable hypertension, and arrhythmia et.al.), initial radiological data performed more than 3 days after SAH onset
Where this trial is running
Hangzhou, Zhejiang
- Second affiliated hospital of Zhejiang University, School of Medicine — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Yuanjian Fang, M.D
- Email: sandman0506@zju.edu.cn
- Phone: 86-18768109541
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.