Exploring inflammation and brain activity in older adults with cognitive disorders
Determination of Inflammatory Markers and Level of Cortical Hyperactivity in Older Adults Undergoing Elective Surgery
This study is testing how inflammation in the body might be connected to brain activity in older adults with cognitive disorders, especially those facing surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | University of Chile Academic / other |
| Locations | 2 sites (Santiago, RM and 1 other locations) |
| Trial ID | NCT05991830 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between inflammatory markers and cortical hyperactivity in older adults undergoing elective surgery. Specifically, it will measure levels of proinflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha, and assess cortical hyperactivity through electroencephalographic changes induced by the anesthetic propofol. The study will involve collecting blood samples from participants aged over 60 years to analyze these markers and their potential link to cognitive impairment associated with Alzheimer's disease.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 60 years of age who are scheduled for elective surgery and can provide informed consent.
Not a fit: Patients with other neurological disorders, severe psychiatric illnesses, or allergies to propofol may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the early biological changes in Alzheimer's disease, potentially leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: While studies have explored aspects of inflammation and cognitive decline, this specific approach of linking inflammatory markers with cortical hyperactivity in a surgical context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults over 60 years of age undergoing elective surgery 2. Able to understand and sign an informed consent form Exclusion Criteria: 1. Diagnosis of other neurological pathologies 2. No active acute or chronic decompensated diseases 3. No severe psychiatric illnesses 4. Propofol allergy
Where this trial is running
Santiago, RM and 1 other locations
- Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chile — Santiago, Rm, Chile (Recruiting)
- Hospital Clinico de la Universidad de Chile — Santiago, Rm, Chile (Recruiting)
Study contacts
- Principal investigator: Pedro Lobos, PhD — University of Chile
- Study coordinator: Antonello Penna, MD, PhD
- Email: apenna@uchile.cl
- Phone: +56956766623
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.