Exploring infertility in Klinefelter Syndrome using organoid models
Unraveling the Klinefelter's Disease Physiopathology by Organoid Model
This study is trying to understand why men with Klinefelter Syndrome have trouble with infertility by looking at their sperm cells in a lab setting.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 5 Years to 50 Years |
| Sex | Male |
| Sponsor | Cliniques universitaires Saint-Luc- Université Catholique de Louvain Academic / other |
| Locations | 1 site (Brussels) |
| Trial ID | NCT05997706 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the infertility associated with Klinefelter Syndrome by isolating and expanding spermatogonial cells from affected patients. Using an organoid model, researchers will analyze how these cells interact with various combinations of somatic cell types within an extracellular matrix hydrogel. The goal is to better understand the physiological mechanisms underlying infertility in men with this genetic condition. Participants will undergo a testicular biopsy to obtain the necessary cells for this research.
Who should consider this trial
Good fit: Ideal candidates for this study are men diagnosed with Klinefelter Syndrome who are experiencing azoospermia and are candidates for testicular sperm extraction.
Not a fit: Patients with Klinefelter Syndrome who also have mosaicism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved fertility preservation strategies for men with Klinefelter Syndrome.
How similar studies have performed: While there have been studies on Klinefelter Syndrome, this specific approach using organoid models is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Klinefelter Exclusion Criteria: * Mosaicism
Where this trial is running
Brussels
- Cliniques Universitaires St Luc — Brussels, Belgium (Recruiting)
Study contacts
- Principal investigator: Christine Wyns, MD, PhD — Cliniques Universitaires St Luc
- Study coordinator: Christine Wyns, MD, PhD
- Email: christine.wyns@uclouvain.be
- Phone: +3227649501
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.