Exploring immune factors in infertile patients with adenomyosis
Study of the Role of Immunologic Factors in Adenomyosis Patients With Infertility
This study is trying to see how immune factors affect infertility in women with adenomyosis to find better ways to help them get pregnant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Peking University Third Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT06123975 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on infertile patients diagnosed with adenomyosis, aiming to investigate the role of immune factors in their infertility. Participants will undergo in vitro fertilization-embryo transfer (IVF-ET) after providing informed consent, with peripheral blood samples collected at various stages to analyze immune cell changes. The study seeks to identify effective clinical intervention targets for infertility associated with adenomyosis by evaluating various patient characteristics and pregnancy outcomes. The findings may provide new insights into the prevention and treatment of this condition.
Who should consider this trial
Good fit: Ideal candidates are women aged 18 to 40 diagnosed with adenomyosis and experiencing infertility.
Not a fit: Patients with other uterine abnormalities, systemic diseases, or severe endocrine and immune disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for infertility in patients with adenomyosis.
How similar studies have performed: While there is ongoing research into adenomyosis and infertility, this specific approach focusing on immune factors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients were diagnosed as adenomyosis by transvaginal ultrasound scans (The criteria for sonographic diagnosis of adenomyosis are with 2 or more of the following: heterogeneous myometrial texture with the presence of globular asymmetric uterus, thickening of the anterior and posterior myometrial wall, irregular cystic areas within the myometrium); * 18≤ age ≤ 40 years old at first outpatient visit in our Reproductive Center; * with regular menstrual cycle. Exclusion Criteria: * Patients with intrauterine adhesion, uterine malformation, submucosal leiomyoma, or ≥ 5.0 cm in diameter leiomyoma; * hydrosalpinx and systemic diseases; * patients with other endocrine severe diseases, immune diseases, tumors and abnormal chromosomes in either partner.
Where this trial is running
Beijing
- Peking University Third Hospital — Beijing, China (Recruiting)
Study contacts
- Principal investigator: Wen Zhang — Peking University Third Hospital
- Study coordinator: Wen Zhang
- Email: chaodongxiehe@163.com
- Phone: 15510659339
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.