Exploring how vitamin D affects immune cell memory
Investigating the Mechanisms of Epigenetic Memory at the Example of the Responsiveness of Human Immune Cells to Vitamin D
PHASE1 · Polish Academy of Sciences · NCT06104111
This study is testing whether taking vitamin D3 can change how immune cells remember things in healthy adults.
Quick facts
| Phase | PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Polish Academy of Sciences (other) |
| Locations | 1 site (Olsztyn) |
| Trial ID | NCT06104111 on ClinicalTrials.gov |
What this trial studies
This study investigates how vitamin D3 supplementation influences the epigenetic programming of immune cells in healthy adults. By following a small group of participants over time, the researchers will measure various molecular and dynamic parameters to understand the mechanistic basis of dietary epigenetic programming. The study aims to uncover how nutritional components like vitamin D3 can create lasting changes in the immune system's response. This approach combines in vivo, in vitro, and in silico methodologies to provide a comprehensive analysis of the effects of vitamin D on the epigenome.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18 to 65 who do not have any significant health issues.
Not a fit: Patients with a history of certain medical conditions, such as kidney stones or severe liver disease, may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations for enhancing immune function and reducing disease risk.
How similar studies have performed: While the specific approach of this study may be novel, previous research has shown that dietary components can influence epigenetic changes in various contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: -Healthy adult (18-65 years) Exclusion Criteria: * Smoker * BMI \> 28 kg/m2 * History of kidney stones, renal failure or dialysis, hypercalcemia, hypo- or hyperparathyroidism, severe liver disease (cirrhosis), or sarcoidosis or other granulomatous diseases, such as active chronic tuberculosis or Wegener's granulomatosis
Where this trial is running
Olsztyn
- Institute of Animal Reproduction and Food Research — Olsztyn, Poland (RECRUITING)
Study contacts
- Study coordinator: Carsten Carlberg, PhD
- Email: c.carlberg@pan.olsztyn.pl
- Phone: +48-89-523-4612
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Immune System Diseases, Infections, Healthy Lifestyle, Vitamin D, Epigenome, Transcriptome