Exploring how the brain represents social connections and loneliness
Official title: Using the Brain to Reveal Mental Representations of Subjective Connection
Run by Columbia University · NCT04577911 · Data updated 2026-11-12
This study looks at how loneliness shows up in the brain to see if understanding it better can help people feel less lonely, even if they have social connections.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 248 (estimated) |
| Sponsor | Columbia University Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | April 1, 2021 |
| Main results expected | November 2026 |
| Study ends | November 2026 |
| Registry record updated | December 16, 2025 |
| Trial ID | NCT04577911 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals who experience loneliness but are safe for MRI scanning and not taking psychiatric medication.
✕Probably not a fit
Patients who are currently taking psychiatric medication or are not safe for MRI scanning will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate how loneliness is represented in the brain using functional magnetic resonance imaging (fMRI). It focuses on understanding the neurobiological mechanisms behind subjective isolation, even among individuals who maintain social relationships. Participants will reflect on their connections to others while undergoing fMRI scans to determine how these representations are organized in the brain and how loneliness affects them. The ultimate goal is to identify potential interventions to reduce feelings of loneliness based on these findings.
Why it matters
Potential benefit: If successful, this study could lead to novel interventions that effectively reduce loneliness and improve mental health outcomes.
How similar studies have gone: Other studies have explored the neurobiological aspects of loneliness, but this specific approach using fMRI to understand subjective connections is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * safe for MRI scanning * not taking psychiatric medication Exclusion Criteria: * not safe for MRI scanning * taking psychiatric medication
Where it's running
-
Columbia University Irving Medical Center
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Meghan Meyer, PhD — Columbia University
- Study coordinator: Meghan L Meyer, PhD
- Email: mlm2378@columbia.edu
- Phone: 650-521-1701
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study tests whether supervised group exercise at fitness clubs helps 75-year-old and older women who live alone feel less lonely and healthier compared to exercising alone or doing usual activities.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.