Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Exploring how the brain represents social connections and loneliness

Official title: Using the Brain to Reveal Mental Representations of Subjective Connection

Run by Columbia University · NCT04577911 · Data updated 2026-11-12

This study looks at how loneliness shows up in the brain to see if understanding it better can help people feel less lonely, even if they have social connections.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment248 (estimated)
SponsorColumbia University
Academic / other
Locations1 site (New York, New York)
StatusRecruiting
StartedApril 1, 2021
Main results expectedNovember 2026
Study endsNovember 2026
Registry record updatedDecember 16, 2025
Trial IDNCT04577911 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals who experience loneliness but are safe for MRI scanning and not taking psychiatric medication.

Probably not a fit

Patients who are currently taking psychiatric medication or are not safe for MRI scanning will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how loneliness is represented in the brain using functional magnetic resonance imaging (fMRI). It focuses on understanding the neurobiological mechanisms behind subjective isolation, even among individuals who maintain social relationships. Participants will reflect on their connections to others while undergoing fMRI scans to determine how these representations are organized in the brain and how loneliness affects them. The ultimate goal is to identify potential interventions to reduce feelings of loneliness based on these findings.

Why it matters

Potential benefit: If successful, this study could lead to novel interventions that effectively reduce loneliness and improve mental health outcomes.

How similar studies have gone: Other studies have explored the neurobiological aspects of loneliness, but this specific approach using fMRI to understand subjective connections is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* safe for MRI scanning
* not taking psychiatric medication

Exclusion Criteria:

* not safe for MRI scanning
* taking psychiatric medication

Where it's running

  • Columbia University Irving Medical Center
    New York, New York, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.