Exploring how neural and metabolic factors influence carbohydrate reward

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between neural mechanisms and carbohydrate metabolism, focusing on how implicit knowledge of caloric content affects food choices. Participants will be given different carbohydrate-rich beverages and meals to assess their responses and the underlying neural signatures involved. The research aims to understand the communication pathways between the gut and the brain that influence dietary preferences and behaviors. By examining these factors, the study seeks to uncover potential interventions for improving dietary choices and addressing metabolic dysfunction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. BMI between 18.5-30 kg/m2
2. Not pregnant or planning to become pregnant during study participation
3. Residing in the Roanoke area and/or willing/able to attend sessions at the Fralin Biomedical Research Institute
4. Able to speak and write in English

Exclusion Criteria:

1. Current inhaled nicotine use
2. History of alcohol dependence.
3. Current or past diagnosis of diabetes or thyroid problems.
4. Taking medications known to influence study measures (including antiglycemic agents, thyroid medications, sleep medications)
5. Active medical or neurologic disorder.
6. Current shift work (typical pattern of work/activity overnight)
7. Previous weight loss surgery
8. Adherence to a special diet within the past 3 months (e.g., low-carb or ketogenic diet, exclusion of food groups/specific macronutrients, intermittent fasting, etc.)
9. Allergy to any food or ingredient included in the study diets, meals, or beverages
10. Currently pregnant or planning to become pregnant during study participation
11. Claustrophobia
12. Contraindications for MRI, including pacemaker, aneurysm clips, neurostimulators, cochlear or other implants, metal in eyes, regular work with steel, etc.

Where it's running

• Fralin Biomedical Research Institute at VTC
  Roanoke, Virginia, United States Recruiting

Study contacts

• Study coordinator: Alexandra G DiFeliceantonio, PhD
• Email: dife@vt.edu
• Phone: 5405262285

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.