Exploring how mothers pass gut bacteria to their babies
Mother-infant Microbiota Transmission and Its Link to the Health of the Baby
This study looks at how mothers pass their gut bacteria to their babies during birth to see how it affects the baby's health and development.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20000 (estimated) |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong, Hong Kong) |
| Trial ID | NCT04117321 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the transmission of gut microbiota from mothers to their infants and its implications for the health of the baby. It focuses on understanding how the maternal microbiome influences the early development of the infant's gut microbiota, which can affect growth, neurodevelopment, and the risk of allergic and cognitive disorders. The study aims to recruit pregnant women who plan to give birth at a local hospital and follow them and their newborns over time to analyze the microbiota changes. The research highlights the importance of early childhood as a critical period for microbiota development and potential manipulation to prevent future health issues.
Who should consider this trial
Good fit: Ideal candidates for this study are pregnant women who plan to give birth at the local hospital and can provide informed consent.
Not a fit: Patients who are not pregnant or those who do not plan to stay in the local area for at least 7 years post-delivery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how maternal health influences infant gut microbiota, potentially leading to strategies for preventing chronic diseases in children.
How similar studies have performed: Other studies have shown promising results in understanding the role of maternal microbiota in infant health, indicating that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Pregnant women Inclusion Criteria: 1. Being pregnant 2. Plan to give birth in local hospital 3. Competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent) 4. Plan to stay in the same local area for at least 7 years post-delivery Exclusion Criteria: No New Born Baby Inclusion Criteria 1. Be a new born baby of an enrolled pregnant woman 2. One of the parents or legal guardian is competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent) Exclusion Criteria: No Father of new born baby Inclusion Criteria 1. Biological father of an enrolled new born baby 2. Competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent) Exclusion Criteria: No
Where this trial is running
Hong Kong, Hong Kong
- Prince of Wales Hospital — Hong Kong, Hong Kong, China (Recruiting)
Study contacts
- Study coordinator: Jessica Ching
- Email: jessicaching@cuhk.edu.hk
- Phone: +852 26373260
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.