Exploring how ketone supplements affect brain stimulation responses
Priming Effects of Ketone Monoester Supplementation on Theta-Burst Stimulation-Induced Plasticity in the Primary Motor Cortex
This study tests if taking ketone supplements can improve the effects of brain stimulation techniques in healthy young adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | Universiti Putra Malaysia Academic / other |
| Locations | 1 site (Serdang, Selangor) |
| Trial ID | NCT06799260 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of ketone monoester supplementation on the efficacy of transcranial magnetic stimulation (TMS) protocols, specifically intermittent and continuous theta-burst stimulation, in healthy young adults. By examining the interaction between ketone supplementation and motor cortex excitability, the research aims to address issues of variability in TMS responses. Participants will be administered either ketone monoester or a placebo while undergoing TMS to assess changes in neuroplasticity. The study focuses on understanding the role of Brain-Derived Neurotrophic Factor (BDNF) in enhancing TMS outcomes.
Who should consider this trial
Good fit: Ideal candidates are healthy young adults aged 18-35 who are right-handed and fully vaccinated against COVID-19.
Not a fit: Patients who are highly active athletes, obese, smokers, or following specific dietary restrictions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for enhancing motor cortex excitability, benefiting rehabilitation strategies for various neurological conditions.
How similar studies have performed: While the approach of combining ketone supplementation with TMS is relatively novel, previous studies have shown promise in enhancing neuroplasticity through various interventions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy young adults (18-35 years old) * Right-handed * Fully vaccinated against COVID-19 Exclusion Criteria: * Subjects with contraindications to TMS based on the screening 13-item questionnaire for TMS safety * Highly active subjects (athletes) * Obese (BMI ≥ 30 kg/m2) * Smokers * Following intermittent fasting or ketogenic diet * Long COVID-19
Where this trial is running
Serdang, Selangor
- Hospital Sultan Abdul Aziz Shah — Serdang, Selangor, Malaysia (Recruiting)
Study contacts
- Study coordinator: Wan Aliaa Wan Sulaiman, FRCP
- Email: wanaliaa@upm.edu.my
- Phone: +60397695560
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.