Exploring how gut bacteria affect cognitive issues in Parkinson's disease
Official title: Microbiome Composition and Function Contributes to Cognitive Impairment and Neuroinflammation in Parkinson's Disease
Run by California State University, San Bernardino · NCT05419453 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study looks at how the bacteria in the gut might affect thinking problems in people with Parkinson's disease to find new ways to help them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 55 Years to 85 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | California State University, San Bernardino Academic / other |
| Locations | 1 site (San Bernardino, California) |
| Trial ID | NCT05419453 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with Parkinson's disease.
✕Probably not a fit
Patients with a history of significant neurological events or gastrointestinal diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the relationship between gut microbiome composition and cognitive impairment in individuals with Parkinson's disease. It aims to identify alternative mechanisms contributing to cognitive decline, beyond the traditional understanding of dopaminergic disruptions. By examining the gut-bacterial composition, the study seeks to uncover potential prognostic indicators and novel treatment targets for cognitive impairment in Parkinson's disease. Participants will be evaluated based on their microbiome profiles and cognitive function.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for cognitive impairment in Parkinson's disease.
How similar studies have gone: While the relationship between gut microbiome and neurological conditions is being explored, this specific approach is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Parkinson's Disease Exclusion Criteria: * Use of antibiotics or immunosuppressant medications within the last 3 months, history of psychiatric hospitalizations, stroke, epilepsy, head injury resulting in a loss of consciousness for more than 30 minutes, Alzheimer's disease or other significant brain injury or neurologic event, history of inflammatory gastrointestinal diseases such as Crohn's, Celiac's disease or irritable bowel syndrome
Where it's running
-
California State University San Bernardino
San Bernardino, California, United States Recruiting
Study contacts
- Study coordinator: Kenya Luna, B.A.
- Email: gutbrainstudy1@gmail.com
- Phone: 9094543135
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.