Exploring how genes and environment affect treatment for developmental dyslexia
Gene x Environment Interplay in Developmental Dyslexia Treatment: A Round-trip Translation Between Humans and Animal
This study is trying to see if playing action video games can help children with dyslexia improve their reading skills by looking at how their genes and environment work together.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 5 Years to 6 Years |
| Sex | All |
| Sponsor | IRCCS Eugenio Medea Academic / other |
| Locations | 1 site (Bosisio Parini, LC) |
| Trial ID | NCT06186882 on ClinicalTrials.gov |
What this trial studies
This study investigates the interplay between genetic factors and environmental influences in the treatment of developmental dyslexia, particularly focusing on the effects of action video games on reading skills. It aims to uncover insights into the pathophysiology of dyslexia and assess how gene-environment interactions impact specific endophenotypes associated with the disorder. The research involves both human participants and animal models to provide a comprehensive understanding of the condition. By examining the magnocellular-dorsal stream's role in attention and reading, the study seeks to identify effective interventions for improving reading abilities in affected children.
Who should consider this trial
Good fit: Ideal candidates for this study are 5-year-old pre-readers with normal intelligence and no history of neurodevelopmental disorders.
Not a fit: Patients with below-average intelligence or any previous diagnosis of neurodevelopmental disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to innovative treatment strategies that enhance reading skills in children with developmental dyslexia.
How similar studies have performed: While the approach of using action video games to improve reading skills is innovative, similar studies have shown promise in enhancing cognitive functions through video game interventions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * 5-years old pre-readers, * normal intelligence quotient, * no main counter indications for magnetic resonance acquisition, * no previous diagnosis of any neurodevelopmental disorders. Exclusion Criteria: * intelligence quotient below the average range, * presence of counter indications for magnetic resonance acquisition, * previous diagnosis of any neurodevelopmental disorders.
Where this trial is running
Bosisio Parini, LC
- Scientific Institute IRCCS E Medea — Bosisio Parini, Lc, Italy (Recruiting)
Study contacts
- Study coordinator: Sara Mascheretti
- Email: sara.mascheretti@lanostrafamiglia.it
- Phone: 031877895
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.