Exploring how exercise and nutrition before sleep affect muscle tissue

The Effect of Exercise and Presleep Nutrition on Muscle Connective Tissue Remodelling

This study is testing if taking a vitamin C collagen supplement before sleep can help healthy, active people improve their muscle tissue after they stop exercising for two weeks.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 12 (estimated)
• Ages: 18 Years to 35 Years
• Sex: All
• Sponsor: University of Toronto (other)
• Locations: 1 site (Toronto, Ontario)
• Trial ID: NCT06054620 on ClinicalTrials.gov

What this trial studies

This study investigates the impact of a vitamin C-enriched collagen supplement taken before sleep on muscle connective tissue remodeling. It aims to assess how dietary glycine is metabolized in the body, particularly in relation to resistance exercise. Participants will be healthy, recreationally active individuals who will abstain from resistance exercise for two weeks prior to the metabolic trials. The study will utilize a glycine tracer to measure changes in muscle tissue at rest and post-exercise.

Who should consider this trial

Good fit: Ideal candidates are healthy, recreationally active males and females aged 18-35 with a normal to overweight BMI.

Not a fit: Patients with health conditions that compromise their ability to engage in strenuous physical activity will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance understanding of muscle recovery and growth through targeted nutrition and exercise strategies.

How similar studies have performed: While the specific combination of presleep nutrition and exercise has not been extensively tested, related studies on collagen supplementation and muscle recovery have shown promising results.

Eligibility criteria

Inclusion Criteria:

* Healthy, recreationally active, male and female participants.
* Healthy will be defined as someone who does not have a health condition that would compromise their ability to safely participate in the strenuous physical activity involved in our study as screened for by the Get Active Questionnaire.
* Willing to abstain from resistance exercise for 2 weeks prior to the first metabolic trial and for the duration of the study.
* Participants must be able to abstain from lower-body resistance and/or plyometric exercise for at least 2 weeks prior to the first metabolic trial.
* Participants will be aged 18-35 years old.
* Participants must be normal to overweight (e.g., BMI 18.5-30).
* Participants are willing to abide by the compliance rules of this study (e.g., abstain from physical activity and alcohol 48h prior to each trial).
* Self-reported regular menstrual cycle (25-35d) within the last 3 months (female participants).

Exclusion Criteria:

* Inability to adhere to any of the compliance rules judged by principal investigator or medical doctor.
* Self-reported regular tobacco use.
* Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.).
* Regular use of anti-inflammatory drugs (e.g., ibuprofen).
* Self-reported regularly sleeping less than an average of 7 hours over 3 days (minimum recommended daily amount).
* Individuals who have participated in studies within the past year involving any of the stable isotopes in the study.
* Use of birth control and discontinued use in the last 3-months (female only).

Where this trial is running

Toronto, Ontario

• Goldring Centre for High Performance Sport at the University of Toronto — Toronto, Ontario, Canada (RECRUITING)

Study contacts

• Study coordinator: Daniel R Moore, PhD

Conditions: Interventional, Collagen, Vitamin C, Carbohydrate placebo