Exploring how early behavioral interventions affect brain development in children with autism
Brain Plasticity of Autism in Response to Early Behavioral Intervention: A Multimodal MRI Study
This study is testing how different early behavioral therapies can change brain development in children with autism to see which methods work best.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 2 Years to 8 Years |
| Sex | All |
| Sponsor | University of Electronic Science and Technology of China Academic / other |
| Locations | 2 sites (Harbin, Heilongjiang and 1 other locations) |
| Trial ID | NCT02807766 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of various early behavioral intervention methods on brain plasticity in children diagnosed with autism. Using multimodal MRI techniques, researchers will collect brain imaging data, eye movement data, stool samples, and clinical scores before and after the interventions. The goal is to understand the pathophysiological mechanisms of autism and evaluate the effectiveness of these interventions. Additionally, the study aims to develop a prediction model for intervention outcomes based on advanced multivariate pattern analysis.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 2 to 8 years with a clinical diagnosis of autism.
Not a fit: Patients with other neurodevelopmental disorders or contraindications to MRI may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide new insights into effective behavioral interventions for autism, potentially improving treatment outcomes for affected children.
How similar studies have performed: Other studies have shown promise in using behavioral interventions for autism, but this approach utilizing multimodal MRI is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age range from 2 to 8 years old. * Clinical DSM-IV diagnosis of autism. Exclusion Criteria: * Subjects with other neurodevelopmental diseases. * Subjects with contraindications to MRI.
Where this trial is running
Harbin, Heilongjiang and 1 other locations
- Department of Children's and Adolescent Health, Public Health College of Harbin Medical University — Harbin, Heilongjiang, China (Recruiting)
- Center for Information in BioMedicine, Key laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China — Chengdu, Sichuan, China (Recruiting)
Study contacts
- Principal investigator: Huafu Chen — School of Life Science and Technology, University of Electronic Science and Technology of China
- Study coordinator: Huafu Chen
- Email: chenhf@uestc.edu.cn
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.