Exploring how dietary fibre affects prostate cancer in older men
Exploiting Human Microbiota-associated in Vivo Models for Mechanistic Studies to Understand the Benefits of Dietary Fibre Supplementation in Patients With Prostate Cancer
University of Aberdeen · NCT06661044
This study is testing if adding more dietary fiber to the diet can help older men with prostate cancer by looking at how it affects their gut health and cancer progression.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 6 (estimated) |
| Ages | 60 Years and up |
| Sex | Male |
| Sponsor | University of Aberdeen (other) |
| Drugs / interventions | nivolumab, pembrolizumab, immunotherapy |
| Locations | 1 site (Aberdeen, Scotland) |
| Trial ID | NCT06661044 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the impact of dietary fibre supplementation on the gut microbiota and its potential benefits for men over 60 with prostate cancer. The research involves feeding mice various dietary fibres and human faecal samples to analyze changes in gut bacteria and beneficial metabolites. The goal is to understand how these dietary changes may influence prostate cancer progression and improve patient outcomes. The study aims to provide insights into dietary interventions that could support men on active surveillance for prostate cancer.
Who should consider this trial
Good fit: Ideal candidates for this study are biologically male individuals over 60 years old who regularly have bowel movements and can provide fresh faecal samples.
Not a fit: Patients currently undergoing cancer treatment or with active gastrointestinal diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer dietary strategies to help slow the progression of prostate cancer in older men.
How similar studies have performed: While dietary interventions in cancer care are being explored, this specific approach focusing on dietary fibre and its effects on prostate cancer is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men (biologically male) over 60 years old. * Regularly pass a bowel motion at least daily. * Able to attend the Rowett Institute for consent procedure and able to arrange delivery of fresh faecal sample to the Rowett Institute on the required study day. Exclusion Criteria: * Living with cancer/on active cancer treatment. * Active ulcerative colitis or Crohn's disease. * Antibiotic therapy within previous 3 months. * Diarrhoea from recent foreign travel. * Known HIV or Hepatitis B positive. * Working directly on specific study for which samples are required. * Line managed or supervised by PI of study.
Where this trial is running
Aberdeen, Scotland
- University of Aberdeen — Aberdeen, Scotland, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Anne E Kiltie, MA, DN, DSc — University of Aberdeen
- Study coordinator: Aliu Moomin, PhD
- Email: aliu.moomin@abdn.ac.uk
- Phone: +441224438718
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Prostate Cancer, Prostate cancer, Dietary fibre, Faecal microbiota transplant, Radiotherapy