Exploring how diet affects blood sugar levels in healthy individuals
Exploring Glycemic Responses Through Continuous Monitoring in a Healthy Population
This study is testing how different diets affect blood sugar levels in healthy people by using a continuous glucose monitor for two weeks.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Zoe Global Limited Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (London) |
| Trial ID | NCT06900439 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate glycemic responses in healthy individuals using continuous glucose monitoring (CGM) over a 14-day period. Participants will wear a CGM device and provide data on their diet and health while consuming a standardized test meal before and after a personalized dietary program. The research seeks to understand the accuracy and variability of CGM in healthy populations and how dietary changes may influence glycemic control and gut microbiome health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18 and older with a BMI of 18.5 kg/m2 or higher, who are enrolled in the ZOE testing program.
Not a fit: Patients with chronic medical conditions that affect glucose metabolism or those who cannot safely consume the standardized meals will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how personalized dietary interventions can optimize glucose control in healthy individuals.
How similar studies have performed: While the approach of using continuous glucose monitoring in healthy populations is gaining interest, this specific study is part of a novel investigation into the interplay between diet, glucose control, and gut microbiome health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Enrolled in the ZOE product \& purchased a Gut Health Retest at month 4 * Any sex * Minimum 18 years of age * Body mass index (BMI) greater than or equal to 18.5 kg/m2 * If under care for any chronic medical conditions (including type 2 diabetes), you have confirmed with your treating physician that this sub study is safe for you. This does not apply to conditions listed in the exclusion criteria. * Able and willing to comply with the study protocol and provide informed consent before your ZOE Gut Health Retest is fulfilled and posted. * Live in the United Kingdom Exclusion Criteria: * Cannot safely eat the standardised meals (part of the ZOE product) which contain standard UK ingredients, e.g. due to allergy or recent gastrointestinal surgery * Cannot safely use the cgm (per manufacturer's contraindications for use including critically ill, pregnant, receiving dialysis, or have an implantable medical device) * Are pregnant * Have had a heart attack (myocardial infarction), stroke/transient ischemic attack (TIA), or major surgery in the last two months * Are unable to read and write in English, as the ZOE app is only available in English. * Are diagnosed with type 1 diabetes and/or require the use of exogenous insulin or oral hypoglycaemic medications to regulate blood sugar levels * Have an active eating disorder (e.g. anorexia nervosa or bulimia nervosa) * Have an active gut or digestive system disease (e.g. IBD, Crohn's disease or ulcerative colitis) * Are undergoing chemotherapy treatment for cancer * Unable to complete study tasks by 31 May 2025
Where this trial is running
London
- ZOE Limited — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Hannah Bernard
- Email: hannahbernard@joinzoe.com
- Phone: +44 330 818 8669
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.