Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Exploring how compensation strategies affect walking in Parkinson's disease

Official title: Unravelling the Neural Mechanisms Underlying Compensation Strategies for Gait Impairments in Parkinson's Disease: a Transnational, Multimodal Approach

Run by Radboud University Medical Center · NCT06142448 · Data updated 2026-11-12

This study tests different ways to help people with Parkinson's disease improve their walking by using a special app to see which methods work best for them.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment384 (estimated)
SponsorRadboud University Medical Center
Academic / other
Locations1 site (Nijmegen)
StatusRecruiting
StartedDecember 1, 2023
Main results expectedDecember 1, 2026
Study endsDecember 1, 2026
Registry record updatedJuly 25, 2025
Trial IDNCT06142448 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include men and women over 18 years old diagnosed with idiopathic Parkinson's disease who can provide informed consent.

Probably not a fit

Patients who have been using compensation strategies daily for the past month or have severe co-morbidities limiting their ability to walk may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of various compensation strategies on gait impairment in individuals with Parkinson's disease. It focuses on understanding how different cueing methods, both external and internal, can help patients improve their walking abilities. The research aims to identify which strategies are most effective for different patients, acknowledging that responses to these cues can vary significantly. By utilizing a cueing app, the study seeks to personalize treatment approaches for better outcomes in gait rehabilitation.

Why it matters

Potential benefit: If successful, this study could lead to more effective, personalized rehabilitation strategies for improving walking in patients with Parkinson's disease.

How similar studies have gone: Previous studies have shown varying success with cueing strategies in Parkinson's disease, but this approach aims to provide a more tailored understanding, making it a novel exploration.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Men and women of age \> 18 years with idiopathic Parkinson's disease;
* Written informed consent.

Exclusion Criteria:

* Daily usage of compensation strategies for the past month;
* Presence of deep brain stimulation (DBS);
* Presence of severe co-morbidity limiting ambulation (e.g. stroke, orthopaedic problems);
* Inability to walk unaided (with the exception of a customary cane);
* Inability to walk for \> 3 minutes consecutively;
* Severe auditory impairments, hampering perception of auditory cues;
* Severe cognitive impairment (MMSE \< 21)

Where it's running

  • Radboudumc
    Nijmegen, Netherlands
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.