Exploring how compensation strategies affect walking in Parkinson's disease
Official title: Unravelling the Neural Mechanisms Underlying Compensation Strategies for Gait Impairments in Parkinson's Disease: a Transnational, Multimodal Approach
Run by Radboud University Medical Center · NCT06142448 · Data updated 2026-11-12
This study tests different ways to help people with Parkinson's disease improve their walking by using a special app to see which methods work best for them.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 384 (estimated) |
| Sponsor | Radboud University Medical Center Academic / other |
| Locations | 1 site (Nijmegen) |
| Status | Recruiting |
| Started | December 1, 2023 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | July 25, 2025 |
| Trial ID | NCT06142448 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include men and women over 18 years old diagnosed with idiopathic Parkinson's disease who can provide informed consent.
✕Probably not a fit
Patients who have been using compensation strategies daily for the past month or have severe co-morbidities limiting their ability to walk may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the impact of various compensation strategies on gait impairment in individuals with Parkinson's disease. It focuses on understanding how different cueing methods, both external and internal, can help patients improve their walking abilities. The research aims to identify which strategies are most effective for different patients, acknowledging that responses to these cues can vary significantly. By utilizing a cueing app, the study seeks to personalize treatment approaches for better outcomes in gait rehabilitation.
Why it matters
Potential benefit: If successful, this study could lead to more effective, personalized rehabilitation strategies for improving walking in patients with Parkinson's disease.
How similar studies have gone: Previous studies have shown varying success with cueing strategies in Parkinson's disease, but this approach aims to provide a more tailored understanding, making it a novel exploration.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women of age \> 18 years with idiopathic Parkinson's disease; * Written informed consent. Exclusion Criteria: * Daily usage of compensation strategies for the past month; * Presence of deep brain stimulation (DBS); * Presence of severe co-morbidity limiting ambulation (e.g. stroke, orthopaedic problems); * Inability to walk unaided (with the exception of a customary cane); * Inability to walk for \> 3 minutes consecutively; * Severe auditory impairments, hampering perception of auditory cues; * Severe cognitive impairment (MMSE \< 21)
Where it's running
-
Radboudumc
Nijmegen, Netherlands Recruiting
Study contacts
- Study coordinator: Cindel Albers
- Email: cindel.albers@radboudumc.nl
- Phone: (024) 366 84 26
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.