Exploring how cerebellar stimulation affects cognitive sequencing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the role of the cerebellum in cognitive functions, particularly its involvement in sequencing tasks. By using transcranial magnetic stimulation (TMS), researchers will assess brain activation during both sequence-demanding and non-sequence-demanding tasks. The study aims to clarify how cerebellar stimulation influences cognitive processing and whether it can enhance performance in tasks that require sequencing. Participants will undergo functional MRI scans to observe brain activity in response to different stimulation conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\) Age 18-50;
* 2\) educational attainment of at least 8 years;
* 3\) capable of giving informed consent;
* 4\) fluent speaker of English by self-report;
* 5\) right handed.

Exclusion Criteria:

* 1\) illicit drug use within 30 days of MRI scanning;
* 2\) neurological or systemic disorder which can cause dementia or cognitive dysfunction;
* 3\) history of an Axis I psychiatric disorder including substance use disorder;
* 4\) history of definite stroke;
* 5\) focal lesion on MRI exam;
* 6\) uncorrected visual deficits by self-report
* 7\) contraindications for MRI scanning
* 8\) use of anxiolytic, antidepressant, neuroleptic, or sedative medication
* 9\) Additional exclusion criteria recommended by Wassermann for TMS neuromodulation, including: History of seizure or a family history of epilepsy, heart disease, intracardiac lines, increased intracranial pressure, history of head trauma, and history of respiratory disease

Where it's running

• Johns Hopkins University School of Medicine
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: John E Desmond, Ph.D. — Johns Hopkins University
• Study coordinator: John E Desmond, Ph.D.
• Email: jdesmon2@jhmi.edu
• Phone: 410-502-3583

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.