Exploring how a dietary supplement affects gut fungi in healthy adults
Official title: Understanding the Efficacy of Dietary Supplement on Fungal Mycobiota in Healthy Volunteers: A Pilot Study
Run by Weill Medical College of Cornell University · NCT06433310 · Data updated 2026-11-12
This study is testing if a dietary supplement called L-Phenylalanine can change the types of fungi in the gut of healthy adults.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | October 17, 2024 |
| Main results expected | December 17, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | June 26, 2026 |
| Trial ID | NCT06433310 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy adults over the age of 18 without any gastrointestinal conditions.
✕Probably not a fit
Patients with a history of gastrointestinal conditions, recent antibiotic or antifungal use, or allergies to L-Phenylalanine will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot study investigates the impact of the dietary supplement L-Phenylalanine on the production of phenylpropionic acid (PPA) and its effects on the fungal populations in the gut microbiome of healthy volunteers. Participants will receive a 14-day supply of L-Phenylalanine capsules, and the study aims to assess how this supplementation influences the diversity of gut mycobiota. The research focuses on understanding the relationship between PPA levels and changes in fungal populations, which may have implications for gut health. The study is designed to fill gaps in knowledge regarding the functional dynamics of gut microbiota and their metabolites.
Why it matters
Potential benefit: If successful, this study could lead to new insights into dietary interventions that promote gut health by modulating fungal populations.
How similar studies have gone: While there is existing research on the effects of dietary supplements on gut microbiota, this specific approach focusing on L-Phenylalanine and its antifungal metabolite PPA is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female adults over the age of 18 years Exclusion Criteria: * History of a diagnosis of any gastrointestinal condition, such as inflammatory bowel syndrome or disease * Antibiotic usage within the past two weeks * Antifungal usage within the past month * Allergy to L-Phenylalanine or individuals with phenylketonuria (PKU) * Adults taking medications known to interact with L-phenylalanine supplements, such as Monoamine Oxidase Inhibitors (MOAI), L-DOPA, and some antipsychotic drugs (complete and extensive drug list will be provided to interested participants during screening) * Pregnant or nursing women
Where it's running
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Belfer Research Building
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Iliyan D Iliev, PhD — Weill Medical College of Cornell University
- Study coordinator: Emilia T Vignogna, BS
- Email: etv4001@med.cornell.edu
- Phone: 505-259-4995
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.