Exploring heart function in adults with systemic right ventricle

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate heart function in adults diagnosed with transposition of the great arteries (TGA) by comparing the heart's performance in systemic right ventricle (SRV) patients to that of subpulmonary right ventricle and systemic left ventricle. It will also assess the relationship between SRV energetics and various patient functional parameters, including results from cardiopulmonary exercise tests and clinical outcomes such as hospitalization and arrhythmias. The study will involve patients aged 18 and older who are either admitted to a specialized heart unit or scheduled for cardiovascular magnetic resonance examinations.

Why it matters

Who can join: the full rules

Inclusion Criteria:Case group:

The study will include patients aged ≥ 18 years with the diagnosis of L-TGA and D-TGA, who:

* are admitted to UNICCA, the Adult Congenital Heart Unit or
* are scheduled for a Cardiovascular Magnetic Resonance examination in this Institution

Control group:

The study will include subjects aged ≥ 18 years who will invited for a Cardiovascular Magnetic Resonance examination in our Institution. This group of control will include n=15 of adult healthy subjects. A further inclusion criteria for the control subjects are age and male proportion comparable to those of the TGA group.

Exclusion Criteria:

* (case and control group)

  * Subjects with intrabody ferromagnetic material precluding subject's safety
  * Subjects with non CMR-conditional devices
  * Subjects with claustrophobia or breath-holding precluding an adequate CMR and 4D Flow images quality
  * Pregnant women

Where it's running

• IRCCS Policlinico San Donato
  San Donato Milanese, Milano, Italy Recruiting

Study contacts

• Study coordinator: Giulia Pasqualin, MD
• Email: giulia.pasqualin@grupposandonato.it
• Phone: +390252774502

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cardiovascular health in children and young adults with chronic conditions

  This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.

  Recruiting Semmelweis University · Budapest and 2 other locations · NCT07086989

• Claudin-2 Immunostaining to Detect Active or Inactive Inflammation in IBD Biopsies

  This study tests whether staining for Claudin-2 in intestinal biopsy samples can help identify active vs. inactive inflammation in people with ulcerative colitis or Crohn's disease.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Mi · NCT07710287

• Using 4D Flow MRI to characterize left ventricular failure

  This project will test whether automated 4D Flow MRI analysis can measure left ventricular dysfunction in adults with severe aortic stenosis who are scheduled for TAVR.

  Recruiting at 2 sites IRCCS Policlinico S. Donato · San Donato Milanese and 1 other locations · NCT07455292

• Measuring aortic wall strength and thickness in ascending aortic aneurysms

  This project tests whether measuring the strength and thickness of removed ascending aortic tissue can help predict rupture risk for patients having surgery for aortic root or ascending aortic aneurysms.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, MI · NCT07453251

• Finding signs of Alzheimer's in people with subjective memory complaints

  The study will test whether inexpensive, easy-to-get measures—like blood markers, EEG and automated speech analysis—can help identify early Alzheimer's in people who notice memory or thinking changes but have normal standard tests.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT07402161

• Risk factors and health impact in people with genetic thoracic aortic disease

  See how lifestyle, stress, reproductive history, and other health issues relate to risk and quality of life in people with genetic thoracic aortic aneurysms.

  Recruiting IRCCS Policlinico S. Donato · Milan · NCT07391293

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.