Exploring genetic factors in pulmonary fibrosis
Official title: Idiopathic Pulmonary Fibrosis, a Disease Initiated by Mucociliary Dysfunction
Run by University of Colorado, Denver · NCT03478553 · Data updated 2026-11-12
This study is trying to see if there are genetic links to pulmonary fibrosis by testing family members of patients with the condition for early signs of lung issues.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 1 site (Aurora, Colorado) |
| Status | Recruiting |
| Started | January 18, 2018 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | March 25, 2025 |
| Trial ID | NCT03478553 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have a family member diagnosed with Idiopathic Pulmonary Fibrosis.
✕Probably not a fit
Patients without a family member diagnosed with IPF will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to screen first-degree family members of individuals diagnosed with Idiopathic Pulmonary Fibrosis (IPF) for early signs of lung fibrosis. The researchers will investigate genetic factors and environmental exposures that may contribute to the development of pulmonary fibrosis. By enrolling both patients with pulmonary fibrosis and their family members, the study seeks to identify genetic loci associated with this condition. Blood samples and questionnaires will be utilized to gather necessary data.
Why it matters
Potential benefit: If successful, this study could lead to early detection and better understanding of genetic risks for pulmonary fibrosis in at-risk individuals.
How similar studies have gone: While genetic studies in pulmonary fibrosis are ongoing, this specific approach focusing on first-degree relatives is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age at least 18 years old * Family member diagnosed with IPF Exclusion Criteria: \- No family member with IPF
Where it's running
-
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States Recruiting
Study contacts
- Principal investigator: David A Schwartz, MD — University of Colorado, Denver
- Study coordinator: Rachel Warren
- Email: rachel.warren@cuanschutz.edu
- Phone: 303-724-8569
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Nerandomilast in IPF and Progressive Fibrosis: Real-World Data
This study tests whether nerandomilast helps slow lung function decline in adults with IPF or progressive fibrotic lung disease in routine clinical care.
-
Photon-counting CT vs standard HRCT to help diagnose IPF and other ILDs
This study tests whether photon-counting CT can improve identifying IPF and other ILDs compared with standard HRCT for patients discussed in multidisciplinary teams.
-
Finger vs. Earlobe Pulse Oximetry During a 6-Minute Walk Test in ILD
This study tests whether finger or earlobe pulse oximetry gives the same oxygen saturation readings during a 6-minute walk in people with interstitial lung disease.
-
Biomarker clues for COPD, IPF, and lung cancer
This study tests whether inflammation, immune, genetic, and epigenetic markers at enrollment can explain how COPD, IPF, or lung cancer present and behave, in order to see if these markers can predict outcomes over a year.
-
Inhaled nintedanib powder for IPF in adults
This study tests whether an inhaled form of nintedanib can safely help adults with idiopathic pulmonary fibrosis.
-
AZD8965 in IPF: see if three doses help IPF patients
This Phase IIb study tests three doses of AZD8965 against placebo in people with idiopathic pulmonary fibrosis, including those who are and aren’t on antifibrotic therapy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.