Exploring genetic factors in childhood asthma
Association Between Cytokines Gene Single Nucleotide Polymorphisms and Type 2 Inflammatory Asthma in Children
This study is trying to see if certain genetic factors are linked to asthma in children to help find better treatments and prevention methods.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 3 Years to 14 Years |
| Sex | All |
| Sponsor | Guangzhou Institute of Respiratory Disease Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06840717 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the association between genetic single nucleotide polymorphisms (SNPs) and type 2 inflammation-related asthma in children. It involves analyzing SNPs, lung function, and type 2 inflammation indicators in children diagnosed with asthma, comparing them to healthy controls. The goal is to identify genetic risk factors that may contribute to asthma and to provide insights for personalized treatment and prevention strategies.
Who should consider this trial
Good fit: Ideal candidates include children diagnosed with asthma who meet specific criteria for type 2 inflammation.
Not a fit: Patients with other respiratory diseases or those who have taken certain medications prior to the study may not benefit from this research.
Why it matters
Potential benefit: If successful, this study could lead to more tailored and effective treatments for children suffering from type 2 asthma.
How similar studies have performed: Other studies have shown promising results in understanding genetic factors in asthma, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. All children with asthma diagnosis accord with the GINA in 2023 edition; 2. Other diseases that could cause wheezing and cough were excluded, such as acute laryngitis, diphtheria, congenital airway abnormalities, and tracheal foreign bodies; 3. In front of the hospital 2 weeks without antibiotics, systemic hormone medication history; 4. There were no other complications, such as congenital heart disease, pneumonia, gastroesophageal reflux disease, muscle dysplasia, etc. Exclusion Criteria: 1. Children who had taken immunosuppressants, antibiotics and other drugs for a long time before admission; 2. Children with primary immunodeficiency disease; 3. The children and their families failed to cooperate or refused the experimental observation.
Where this trial is running
Guangzhou, Guangdong
- Guangzhou institute of respiratory disease — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Study coordinator: Lihong Sun, M.D.
- Email: sunlihong9797@126.com
- Phone: 13719240285
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.