Exploring genetic differences in malignant pleural mesothelioma
Molecular, Pathologic Intra Tumoral Heterogeneity in Malignant Pleural Mesothelioma
This study is collecting tumor samples from people with malignant pleural mesothelioma to see how genetic differences affect the disease and help improve future treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 95 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT04823741 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on malignant pleural mesothelioma (MPM), a rare cancer often linked to asbestos exposure. The research aims to collect large tumor samples during routine surgical procedures, specifically through pleural biopsies conducted via video-assisted thoracoscopic surgery (VATS). By harvesting these samples, the study seeks to enhance the understanding of genetic and tumor mechanisms associated with MPM, contributing to a tissue bank for future analysis. The findings could provide insights into the intra-tumoral heterogeneity of this disease.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have suspected malignant pleural mesothelioma and are scheduled for a VATS biopsy.
Not a fit: Patients who are pregnant, have mental health disorders, or are under protective regimens may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment strategies for patients with malignant pleural mesothelioma.
How similar studies have performed: While this approach is focused on a specific aspect of MPM, similar studies exploring tumor heterogeneity in other cancers have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age \>18 * suspected MPM requiring VATS biopsy after multidisciplinary oncologic board validation * patient able to understand study objectives and able to give an informed consent * patient affiliated to an healthcare society. Exclusion Criteria: * pregnancy * mental disease, psychiatric disorder * patient under protection regimen
Where this trial is running
Bron
- Département de chirurgie thoracique — Bron, France (Recruiting)
Study contacts
- Study coordinator: Jean-Michel MAURY, MD
- Email: jean-michel.maury@chu-lyon.fr
- Phone: 04.72.35.75.90
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.