Exploring coronary artery disease progression using radial wall strain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the predictive value of radial wall strain (RWS) derived from angiograms for the progression of coronary artery lesions compared to lesion vulnerability assessed by optical coherence tomography (OCT). It involves a multicenter, prospective cohort of individuals who have experienced an acute myocardial infarction within the last 45 days. The study aims to determine if RWS can effectively predict disease progression at one year, using a specific threshold for identifying vulnerable lesions. The findings may help optimize strategies for identifying high-risk plaques in patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* General Inclusion Criteria:

  1. Age ≥18 years
  2. Acute myocardial infarction ≤ 45 days
  3. Planned coronary angiography examination or potential interventional treatment
* Angiographic Inclusion Criteria:

  1. The presence of at least 1 non-flow-restricting lesion (visually estimated diameter stenosis: 30%-80%; QFR \> 0.80) in any non-infarct related artery with RVD ≥2.5 mm by visual assessment

Exclusion Criteria:

* General exclusion Criteria:

  1. Cardiogenic shock
  2. Pregnant or woman of child-bearing potential
  3. Life expectancy less than 1 year for non-cardiac causes
  4. Unable to tolerate contrast agents or anticoagulant/antiplatelet therapy
  5. Prior CABG or planned CABG
* Angiographic exclusion Criteria:

  1. Poor angiographic image quality precluding vessel contour detection or with suboptimal contrast opacification, branch ostium cannot be shown clearly, severe overlap in the stenosed segment or severe tortuosity of any interrogated vessel deemed not amenable to QFR or RWS measurement
  2. An interrogated lesion require surgical bypass grafting
  3. Unable to judge culprit lesion or infarct-related artery according to current evidence

Where it's running

• Lei Song
  Beijing, China Recruiting

Study contacts

• Principal investigator: Lei Song, MD — Chinese Academy of Medical Sciences, Fuwai Hospital
• Study coordinator: Lei Song, MD
• Email: drsong@vip.163.com
• Phone: 01088322564

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Does Caffeine or Alcohol Change Pupil Reactions? A Test in Healthy Adults

  This study tests how caffeine and alcohol affect pupil responses and eye movements, and whether these changes can indicate recent intake, in adults aged 30-50.

  Recruiting National University of Singapore · Singapore · NCT07625358

• See if early heart plaque can be reduced with statin and colchicine in people at risk

  This trial tests whether high‑intensity statin and low‑dose colchicine, taken alone or together, can reduce heart plaque in people at risk for heart disease.

  Recruiting at 17 sites Phase 3 Duke University · Birmingham, Alabama and 22 other locations · NCT07232069

• Clinical features, treatments, and outcomes in inflammation-associated non-rapidly-progressive coronary artery disease

  This study will see how current treatments, inflammation markers, and patient characteristics relate to outcomes in people with inflammation-associated non-rapidly-progressive coronary artery disease (INR-CAD).

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06845410

• Effects of PCSK9 inhibitors on heart artery plaque

  This study tests if adding PCSK9 inhibitors to statin therapy can improve heart artery plaque in Asian patients with early-onset coronary artery disease.

  Recruiting Phase 4 First Affiliated Hospital of Xinjiang Medical University · Ürümqi, Xinjiang · NCT06520904

• Investigating characteristics of a special type of coronary artery disease

  This study is trying to understand the unique features of a fast-progressing type of coronary artery disease by comparing patients with this condition to those with a more common form of the disease.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06007248

• Evaluating comprehensive treatment for rapidly-progressive coronary artery disease

  This study is testing a new treatment plan for people with rapidly-progressive coronary artery disease that includes medication and procedures to see if it helps them feel better and manage their condition.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05860400

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.