Exploring brain response variability to stimulation in healthy individuals
Exploring the Cortical Hemodynamic Variability of Prefrontal ITBS: a Concurrent TBS/fNIRS Study
This study is testing how different factors like age and mood affect the brain's response to a specific type of stimulation in healthy people.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | The Hong Kong Polytechnic University Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06104462 on ClinicalTrials.gov |
What this trial studies
This study investigates how different factors affect the brain's response to intermittent theta-burst stimulation (iTBS) in healthy individuals. Using a concurrent TBS/fNIRS technique, researchers will measure cortical excitability on multiple days while assessing various inter- and intra-individual factors such as age, gender, daily mood, and physical activity. The goal is to understand the variability in neurophysiological responses to optimize the therapeutic use of iTBS.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy individuals who can understand verbal instructions and have completed at least six years of formal education.
Not a fit: Patients with current or past psychiatric or neurological disorders, severe internal illnesses, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of iTBS as a therapeutic tool for various neurological and psychiatric conditions.
How similar studies have performed: While there have been studies on iTBS, this specific investigation into the variability of responses based on individual factors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthiness based on history and psychiatric assessment * being able to hear and understand the verbal instructions * completed at least 6 years of formal education Exclusion Criteria: * a current or past diagnosis of psychiatric, neurological disorders, or severe internal illness * any conditions that will contraindicate to iTBS or fNIRS * psychiatric disorders in their first-degree relatives * pregnancy
Where this trial is running
Hong Kong
- The Hong Kong Polytechnic University — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Georg Kranz, PhD — The Hong Kong Polytechnic University
- Study coordinator: Georg Kranz, PhD
- Email: georg.kranz@polyu.edu.hk
- Phone: 2766
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.