Exploring brain function related to emotion regulation in obese patients with and without binge eating disorder
Neurofunctional Characterization of Emotional Regulation and Its Links With the Eating Behaviour of Patients Suffering From Obesity, With or Without Binge Eating Disorder and Seeking Bariatric Surgery. Pilot Study
This study is trying to see how the brain handles emotions in people with obesity, with or without binge eating disorder, to find better ways to help them manage their eating habits.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | CHU de Reims Academic / other |
| Locations | 1 site (Reims) |
| Trial ID | NCT05131256 on ClinicalTrials.gov |
What this trial studies
This study investigates the neurofunctional profiles of emotion regulation in patients suffering from obesity, with or without binge eating disorder (BED), compared to healthy participants. Using functional MRI (fMRI), the research aims to understand how emotional regulation affects eating behaviors and psychological profiles in these patients. By identifying the neural correlates of emotion dysregulation, the study seeks to provide insights that could lead to new therapeutic approaches for obesity and BED. Participants will include individuals seeking bariatric surgery who meet specific inclusion criteria.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 60 who are obese, seeking bariatric surgery, and have a diagnosis of binge eating disorder.
Not a fit: Patients with current substance use disorders, neurological disorders, or severe mental health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved therapeutic strategies for managing obesity and binge eating disorder.
How similar studies have performed: While there is limited research specifically on the neurofunctional profiles of emotion regulation in this patient population, similar studies have shown promise in understanding emotional dysregulation in obesity.
Eligibility criteria
Show full inclusion / exclusion criteria
Group 1: Patients suffering from obesity, seeking bariatric surgery, and with BED. Inclusion criteria: * Patients between 18 and 60 years old, men or women, right-handed * Having a diagnosis of obesity class 2 or 3 and seeking bariatric surgery * With Binge eating disorder (BED) * Possibility to the use of MRI * Patients being a native French speaker * Patients enrolled in the national healthcare insurance program * Patients consenting to participate to the study Exclusion criteria: * The presence of a current substance use disorder as defined by DSM-5 criteria * The presence of neurological disorders or head trauma * The presence of any intellectual disability, of pervasive developmental disorders or learning difficulties (especially of dysphasia and dyspraxia) * A current mood episode as defined by DSM-5 criteria * A diagnosis of schizophrenia or of bipolar disorder according to DSM-5 criteria * Handling of psychotropics substances * A sensorial impairment uncorrected (visual and/or hearing) * Contraindication to the use of MRI * Pregnant woman and people particularly protected by the law Group 2: Patients suffering from obesity, seeking bariatric surgery, and without BED. Inclusion criteria: * Patients between 18 and 60 years old, men or women, right-handed * Having a diagnosis of obesity class 2 or 3 and seeking bariatric surgery * Without Binge eating disorder (BED) * Possibility to the use of MRI * Patients being a native French speaker * Patients enrolled in the national healthcare insurance program * Patients consenting to participate to the study Exclusion criteria: * The presence of a current substance use disorder as defined by DSM-5 criteria * The presence of neurological disorders or head trauma * The presence of any intellectual disability, of pervasive developmental disorders or learning difficulties (especially of dysphasia and dyspraxia) * A current mood episode as defined by DSM-5 criteria * A diagnosis of schizophrenia or of bipolar disorder according to DSM-5 criteria * Handling of psychotropics substances * A sensorial impairment uncorrected (visual and/or hearing) * Contraindication to the use of MRI * Pregnant woman and people particularly protected by the law Group 3: Healthy participants. Inclusion criteria: * Men or women, right-handed, between 18 and 60 years old * Without overweight nor obesity * Native French speaker * Individuals enrolled in the national healthcare insurance program * Individuals consenting to participate to the study Exclusion criteria: * Past obesity * The presence of neurological disorders or head trauma * The presence of any intellectual disability, of pervasive developmental disorders or learning difficulties (especially of dysphasia and dyspraxia) * Handling of psychotropics substances * A sensorial impairment uncorrected (visual and/or hearing) * Contraindication to the use of MRI * Pregnant woman and people particularly protected by the law * A current mood episode as defined by DSM-5 criteria * A diagnosis of schizophrenia or of bipolar disorder according to DSM-5 criteria * The presence of a current substance use disorder as defined by DSM-5 criteria * A diagnosis of eating disorder as defined by DSM-5 criteria
Where this trial is running
Reims
- Damien JOLLY — Reims, France (Recruiting)
Study contacts
- Study coordinator: Farid BENZEROUK
- Email: fbenzerouk@chu-reims.fr
- Phone: 03 26 78 33 94
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.