Exploring brain connectivity patterns in post-stroke patients
Altered Structural-functional Connectivity Coupling on Chronic Subcortical Stroke: a Resting-state fMRI Study
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · NCT05648552
This study looks at how the connections in the brains of stroke survivors relate to their ability to move, to see if understanding these patterns can help improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 70 (estimated) |
| Ages | 30 Years to 75 Years |
| Sex | All |
| Sponsor | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (other) |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT05648552 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between structural and functional connectivity in the brains of post-stroke survivors who experience motor dysfunction. Using multimodal MRI, the study aims to identify how these connectivity patterns correlate with motor function recovery. By analyzing the anatomical and functional connections in the brain, researchers hope to uncover biological markers that could inform treatment strategies for improving motor deficits in stroke patients.
Who should consider this trial
Good fit: Ideal candidates are right-handed individuals aged 30 to 75 who have experienced a first unilateral subcortical stroke more than three months prior and have stable vital signs.
Not a fit: Patients with contraindications for MRI, other brain diseases, or severe cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved assessment and treatment strategies for motor dysfunction in post-stroke patients.
How similar studies have performed: Previous studies have suggested that analyzing structural and functional connectivity can provide valuable insights, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Comply with the diagnostic criteria of "Stroke" in the 2010 "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China," and confirmed by head CT or MRI. 2. First onset unilateral subcortical stroke (basal ganglia, thalamus, internal capsule, corona radiata, lateral ventricles, etc.). 3. Age ranged from 30 to 75 years old. 4. Right-handedness before stroke. 5. Greater than three months since stroke onset and Brunnstrom graded as III-VI; 6. The condition and vital signs are stable. 7. Sign the informed consent form. Exclusion Criteria: 1. Any contraindications for the MRI examination. 2. History of other brain diseases and drug dependency. 3. Unstable conditions or accompanied by malignant and rapidly progressing diseases, such as severe atrial fibrillation. 4. Serious communication barriers, cognitive impairment, or cooperation with difficulties.
Where this trial is running
Nanjing, Jiangsu
- Nanjing Drum Tower Hospital — Nanjing, Jiangsu, China (RECRUITING)
Study contacts
- Study coordinator: Wenjun Hong
- Email: hongwenjun1989@126.com
- Phone: +86 13851924571
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke, Motor Activity, Motor dysfunction, MRI, structural connectivity, functional connectivity