Exploring brain connectivity in autism and the effects of neurostimulation
Discerning the Abnormal Functional Connectivity Involving the Social Reciprocity Network in Autism Spectrum Disorder and the Impact of Transcranial Magnetic Stimulation in Mitigating the Abnormalities
This study is testing if a brain stimulation treatment can help improve social skills in people with autism by looking at how their brain connections work.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 12 (estimated) |
| Ages | 13 Years to 18 Years |
| Sex | All |
| Sponsor | Christiana Care Health Services Academic / other |
| Locations | 1 site (Newark, Delaware) |
| Trial ID | NCT06807684 on ClinicalTrials.gov |
What this trial studies
This trial investigates the abnormalities in neuronal connectivity within the social reciprocity network in individuals with Autism Spectrum Disorder (ASD). The researchers hypothesize that these connectivity issues contribute to the core deficits associated with ASD. By utilizing quantitative electroencephalography (QEEG) to analyze coherence and spectral power, the study aims to understand the neuronal dynamics affecting social cognition. Additionally, the trial will assess the impact of transcranial magnetic stimulation (rTMS) on these abnormalities to potentially improve social functioning in participants.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who meet the DSM-V criteria for Autism Spectrum Disorder.
Not a fit: Patients with significant anxiety or contact avoidance that prevents cooperation with the procedure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved social cognition and functioning in individuals with autism.
How similar studies have performed: While the approach of using neurostimulation in autism is being explored, this specific focus on the social reciprocity network is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria 1\. Fulfilling the DSM-V criteria for ASD and confirmed by CARS2, HF Exclusion criteria 1. Patients with ASD exhibiting significant anxiety or contact avoidance, precluding them from cooperating with the procedure 2. Patients with a known diagnosis of seizures 3. Presence of any metallic implants or devices in the head or neck area 4. Pregnant women
Where this trial is running
Newark, Delaware
- Christiana Care — Newark, Delaware, United States (Recruiting)
Study contacts
- Study coordinator: Mitra Assadi, MD
- Email: mitra.assadi@christianacare.org
- Phone: 3026233017
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.