Exploring brain blood flow in obese patients
Hemodynamic and Functional Characteristics of the Cerebral Circulation in Obesity
This study looks at how obesity affects blood flow in the brain and checks if losing weight after surgery changes that for people who are overweight.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 59 Years |
| Sex | All |
| Sponsor | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz Academic / other |
| Locations | 1 site (Móstoles, Madrid) |
| Trial ID | NCT06067113 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the differences in cerebral hemodynamics and vascular characteristics between obese individuals and those with normal weight. It will also assess changes in these characteristics following significant weight loss after bariatric surgery. The study utilizes supraaortic and transcranial duplex imaging techniques to gather data on brain arteries and blood flow velocity. By understanding these relationships, the research seeks to shed light on the impact of obesity on cerebral vascular health.
Who should consider this trial
Good fit: Ideal candidates for this study are morbidly obese individuals with a BMI over 40 or a BMI of 35 with obesity-related health conditions who are indicated for bariatric surgery.
Not a fit: Patients under 18 or over 59 years old, pregnant women, or those with acute heart disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how obesity affects brain blood flow, potentially leading to improved treatment strategies for related vascular conditions.
How similar studies have performed: While there is substantial research on obesity's impact on large-vessel atherosclerosis, studies specifically focusing on cerebral vasculature in obese patients are limited, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA * Morbid obesity (BMI above 40) or a BMI of 35 and obesity-related health conditions * Indication for bariatric surgery as losing weight treatment * Sign informed consent EXCLUSION CRITERIA * Age under 18 years or over 59 years * Pregnancy * Patients with acute heart disease * Denial or withdrawal of the informed consent * Absence of acoustic window despite the use of eco-enhancers. * Inability to channel a peripheral line. * The subject fails to achieve, after surgery, a weight loss of at least 25% of the initial weight
Where this trial is running
Móstoles, Madrid
- Hospital Universitario Rey Juan Carlos — Móstoles, Madrid, Spain (Recruiting)
Study contacts
- Study coordinator: Jose Fernandez-Ferro, MD MSc
- Email: jose.fferro@hospitalreyjuancarlos.es
- Phone: 659136245
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.