Exploring brain activity related to urination in patients with neobladders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the brain activity associated with urination intention and self-controlled urination behavior in patients who have undergone orthotopic sigmoid neobladder surgery. Using task-state functional magnetic resonance imaging (fMRI), the study aims to identify specific brain regions involved in lower urinary tract function. Participants must be right-handed and at least three months post-surgery, with no contraindications to fMRI. The findings could enhance our understanding of urinary function in neobladder patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Being right-handed;
2. 3 months or more after operation;
3. No contraindications to fMIR examination;
4. Voluntarily sign informed consent.

Exclusion Criteria:

1. History of bladder radiotherapy;
2. History of prostate cancer;
3. Suffering from diseases affecting abdominal pressure;
4. History of abnormal brain anatomy, craniocerebral surgery, craniocerebral tumor, and craniocerebral radiotherapy;
5. History of mental disorders, Parkinson's disease, Alzheimer's disease, epilepsy, cerebral infarction, cerebral hemorrhage;
6. Claustrophobia or carrying metal implants that are not suitable for fMRI examination;
7. Diseases affecting lower urinary tract function (such as spinal cord injury, diabetic peripheral neuropathy, etc.);
8. Urethral stricture;
9. Refusing to sign the informed consent form for clinical projects;
10. Other conditions that were not suitable for inclusion according to the investigator's judgment.

Where it's running

• Zhujiang Hospital of Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Chunxiao Liu — Southern Medical University, China
• Study coordinator: Chunxiao Liu
• Email: liuchx888@163.com
• Phone: 13302296795

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.