Exploring brain activity related to urination in patients with neobladders
Neuroimaging Study of Supraspinal Control of Lower Urinary Tract Function in Patients with Orthotopic Sigmoid Neobladder.
This study is testing how the brain works during urination in patients who have had neobladder surgery to better understand their urinary function.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Zhujiang Hospital Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT05558111 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the brain activity associated with urination intention and self-controlled urination behavior in patients who have undergone orthotopic sigmoid neobladder surgery. Using task-state functional magnetic resonance imaging (fMRI), the study aims to identify specific brain regions involved in lower urinary tract function. Participants must be right-handed and at least three months post-surgery, with no contraindications to fMRI. The findings could enhance our understanding of urinary function in neobladder patients.
Who should consider this trial
Good fit: Ideal candidates are right-handed individuals who are at least three months post-orthotopic sigmoid neobladder surgery.
Not a fit: Patients with a history of bladder radiotherapy, prostate cancer, or other conditions affecting lower urinary tract function may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with orthotopic neobladders by enhancing our understanding of their urinary control mechanisms.
How similar studies have performed: While functional imaging studies have explored brain activity related to urinary function, this specific approach in neobladder patients is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Being right-handed; 2. 3 months or more after operation; 3. No contraindications to fMIR examination; 4. Voluntarily sign informed consent. Exclusion Criteria: 1. History of bladder radiotherapy; 2. History of prostate cancer; 3. Suffering from diseases affecting abdominal pressure; 4. History of abnormal brain anatomy, craniocerebral surgery, craniocerebral tumor, and craniocerebral radiotherapy; 5. History of mental disorders, Parkinson's disease, Alzheimer's disease, epilepsy, cerebral infarction, cerebral hemorrhage; 6. Claustrophobia or carrying metal implants that are not suitable for fMRI examination; 7. Diseases affecting lower urinary tract function (such as spinal cord injury, diabetic peripheral neuropathy, etc.); 8. Urethral stricture; 9. Refusing to sign the informed consent form for clinical projects; 10. Other conditions that were not suitable for inclusion according to the investigator's judgment.
Where this trial is running
Guangzhou, Guangdong
- Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: Chunxiao Liu — Southern Medical University, China
- Study coordinator: Chunxiao Liu
- Email: liuchx888@163.com
- Phone: 13302296795
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.