Exploring biomarkers for early detection of pancreatic tumors
Official title: A Prospective, Open Large Cohort Study of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas
Run by Zhejiang University · NCT05433935 · Data updated 2026-11-12
This study is trying to find early warning signs in blood, urine, and other samples from patients with a specific type of pancreatic tumor to see if they can help predict when it might turn cancerous.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Years to 90 Years |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Status | Recruiting |
| Started | July 1, 2022 |
| Main results expected | June 30, 2032 |
| Study ends | December 31, 2033 |
| Registry record updated | January 27, 2023 |
| Trial ID | NCT05433935 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals clinically diagnosed with IPMN who do not have other malignant tumors.
✕Probably not a fit
Patients with mental disorders affecting cognition or those with serious blood diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify biomarkers that can predict the early carcinogenesis of Intraductal Papillary Mucinous Neoplasm (IPMN) of the pancreas. It will involve the prospective enrollment of patients diagnosed with IPMN, who will provide biological samples such as blood, urine, feces, and saliva for analysis. The study focuses on utilizing multi-omics approaches to assess the predictive accuracy of these biomarkers for malignant transformation of IPMN. Secondary endpoints include evaluating surgical resection rates and survival outcomes post-surgery.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and better management of pancreatic tumors, improving patient outcomes.
How similar studies have gone: While there have been studies exploring biomarkers in pancreatic conditions, this specific approach focusing on IPMN and multi-omics is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * clinically diagnosed as IPMN; * without other malignant tumor; * agree to sign informed consent. Exclusion Criteria: * with mental disorders which can affect cognition and cooperation; * with serious blood diseases or taking drugs that can affect peripheral blood
Where it's running
-
the First Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Study coordinator: Tingbo Liang, PhD
- Email: liangtingbo@zju.edu.cn
- Phone: +86 19941463683
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Blood protein biomarkers to help diagnose pancreatic cancer in adults
This study tests whether blood protein biomarkers can help detect pancreatic ductal adenocarcinoma and tell it apart from chronic pancreatitis and mucinous pancreatic lesions, and whether combining markers with CA 19-9 improves accuracy.
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Liquid biopsy biomarkers to detect and monitor pancreatic cancer
Researchers test blood-based microRNA signals to see if they can identify pancreatic cancer risk or early disease in people with familial or hereditary risk or mucinous cysts.
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Why surgery was performed for IPMN and the outcomes
This project looks at medical records of adults who had surgery for IPMN to see if operations were done for suspected cancer versus incidental findings and how those patients did afterward.
-
AI-enhanced low-dose CT to screen for pancreatic cancer
This project will test whether an AI tool called PANDA can read low-dose CT scans to find early pancreatic cancer in people aged 50 and older.
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AI-based early detection of pancreatic cancer using routine CT scans
This study is testing an AI system that uses regular CT scans to see if it can help find pancreatic cancer early in people who are at high risk.
-
Registry for pancreatic cysts at UCSF
This study is setting up a registry to track patients with pancreatic cysts to see how these cysts change over time and to help doctors make better treatment decisions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.