Exploring biomarkers for cognitive disorders in China

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to establish a large-scale dementia cohort in China by enrolling 3000 patients with pre-dementia stages and various dementia subtypes. It will collect comprehensive data, including demographics, clinical symptoms, neuropsychological assessments, neuroimaging, and biological samples. Participants will undergo annual follow-ups to monitor changes in their cognitive status, allowing researchers to compare clinical phenotypes and identify potential biomarkers for early diagnosis and progression of dementia. The study seeks to address the lack of longitudinal data on cognitive decline in the Chinese population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female patients aged ≥40 and ≤90years;
* Chief complaint or others describe a cognitive decline;
* Ability to communicate in Chinese;
* The patients and their families were informed and signed the informed consent.

Exclusion Criteria:

* MMSE\<10;
* There are other neurological diseases that can cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, traumatic brain injury, normal intracranial pressure hydrocephalus, etc.);
* There are other systemic diseases that can cause cognitive impairment (such as hepatic insufficiency, renal insufficiency, Thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);
* Suffering from a disease that cannot cooperate with the completion of cognitive examination;
* There are contraindications to nuclear magnetic resonance;
* There is mental and neurodevelopmental delay;
* Refuse to draw blood;
* Refuse to sign the informed consent.

Where it's running

• Capital Medical University Xuanwu Hospital
  Beijing, China Recruiting

Study contacts

• Principal investigator: Cuibai Wei — Xuan Wu Hospital of Capital Medical University, Beijing, China, 100053
• Study coordinator: Cuibai Wei
• Email: weicb@xwhosp.org
• Phone: 83198319

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.