Exosome injections to improve atrophic facial scars
Evaluation of Intralesional Exosomes Versus Intralesional Saline in The Treatment of Atrophic Scars: A Randomized Controlled Trial
This trial will test whether injecting exosomes into atrophic facial scars improves their appearance and texture compared with saline injections in adults with multiple facial scars.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 12 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Zagazig University Government |
| Locations | 1 site (Zagazig, Zagazig) |
| Trial ID | NCT07569666 on ClinicalTrials.gov |
What this trial studies
Adults with multiple atrophic scars on one or both sides of the face will be randomly assigned to receive intralesional exosome injections or saline injections as a control, with both patients and evaluators blinded to allocation. Treatments will be given at Zagazig University Hospitals and outcomes will include scar appearance, texture, and safety measures. Participants must be over 18, willing to give informed consent, and free of infection or hypersensitivity at the treatment site. Pregnant people and those with only a single scar or unrealistic expectations are excluded.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with multiple atrophic facial scars who can attend Zagazig University Hospitals and are willing to provide informed consent.
Not a fit: Patients with only one scar, active infection at the scar site, pregnancy, known hypersensitivity to components, or unrealistic expectations may not benefit from this intervention.
Why it matters
Potential benefit: If successful, the treatment could meaningfully improve the look and feel of atrophic scars and boost patient confidence.
How similar studies have performed: Early laboratory and small clinical studies suggest exosomes may aid skin repair, but well-controlled clinical evidence for scar improvement is still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Age \>18 years * Either gender * Scars of any duration * Multiple scars at one side or both sides of the face. * Patients are willing to sign written informed consent statements before beginning treatment. Exclusion Criteria: * Pregnant females. * Patients with one scar. * Hypersensitivity to any of the used treatments. * Patient with infection at the site of the scar. * Patients with unrealistic expectations. * Patient refusing to sign on the consent.
Where this trial is running
Zagazig, Zagazig
- Zagazig University Hospitals — Zagazig, Zagazig, Egypt (Recruiting)
Study contacts
- Study coordinator: mona Elradi
- Email: monaelradi@medicine.zu.edu.eg
- Phone: +201067070550
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.