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Clinical trial Recruiting at 1 site Interventional Ages 20 to 85

Exercise with blood flow restriction for adults with and without chronic kidney disease

Official title: The Feasibility and Effects of Exercise Training Combined With Blood Flow Restriction Training on Exercise Capacity and Exercise Tolerance in Patients With Chronic Kidney Disease

Run by National Cheng Kung University · NCT07288905 · Data updated 2026-11-12

This project will test whether adding blood flow restriction to aerobic and resistance exercise improves heart‑lung fitness and exercise ability in adults with chronic kidney disease and in healthy adults.

Quick facts

Study typeInterventional
Ages20 Years to 85 Years
SexAll
Enrollment120 (estimated)
SponsorNational Cheng Kung University
Academic / other
Locations1 site (Tainan)
StatusRecruiting
StartedOctober 4, 2025
Main results expectedDecember 31, 2027
Study endsDecember 31, 2030
Registry record updatedDecember 17, 2025
Trial IDNCT07288905 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 20–85 years old who either have stable CKD (eGFR <90 ml/min/1.73 m2 for >3 months) or are healthy volunteers, and who can attend supervised sessions at the study site, are eligible if they do not meet exclusion criteria.

Probably not a fit

Patients with severe uncontrolled metabolic, cardiovascular, pulmonary, or musculoskeletal disease, unstable vital signs, pregnancy, active cancer, recent infection, pacemakers, a tendency to bruise, or other exclusion conditions are unlikely to benefit or are not eligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 20–85 with stable chronic kidney disease (eGFR <90 ml/min/1.73 m2 for over 3 months) and healthy volunteers will be enrolled at National Cheng Kung University Hospital. Participants will follow supervised aerobic and resistance exercise programs, with some sessions using blood flow restriction to allow lower training loads. Cardiopulmonary tests including VO2 peak and measures of exercise capacity will be taken before and after the intervention to compare effects. People with severe uncontrolled metabolic, cardiovascular, pulmonary, or musculoskeletal conditions, recent infection, pregnancy, active cancer, pacemakers, bleeding tendency, or unstable vital signs are excluded.

Why it matters

Potential benefit: If successful, adding blood flow restriction could help people with CKD improve fitness, reduce fatigue, and preserve muscle while using lower exercise loads.

How similar studies have gone: Prior research shows exercise improves VO2 peak in CKD and that blood flow restriction can produce similar gains to high‑load training in older adults, but applying BFR specifically in CKD patients is less well studied.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Healthy

Inclusion Criteria:

• Aged 20\~85 years old

Exclusion Criteria:

* Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)
* Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)
* Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months
* Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)
* Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \>100 bpm)
* Prone to bruising
* Recent inflection \< 1 month
* Pregnancy
* Kidney function impairment
* Cancer
* Simultaneously participating in other research

CKD

Inclusion criteria:

* Aged 20\~85 years old
* eGFR\< 90 ml/min/1.73 m2 over 3 months
* Stable condition without worsening in the past 3 months
* Ability to understand and follow verbal commends and cooperate with an exercise training program

Exclusion criteria:

* Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)
* Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)
* Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months
* Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)
* Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \>100 bpm)
* Abnormal blood biochemical parameters (e.g., white blood cell count \<2500/mm³, hemoglobin \<8 mg/dL, total bilirubin \>3 mg/dL, liver enzymes (GOT/AST, GPT/ALT) \>3 times the upper limit of normal, platelet count \<75,000/mm³
* Sensory or motor dysfunctions that affect walking ability
* Diagnosed systemic diseases under ongoing treatment (e.g., systemic lupus erythematosus, cancer, malignancies).

Where it's running

  • National Cheng Kung University Hospital
    Tainan, Taiwan     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Chronic Kidney Disease 283National Cheng Kung University 9
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.