Exercise versus calorie restriction: effects on tumor and muscle protein synthesis in prostate cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Men with stage I–III prostate cancer scheduled for prostatectomy will be assigned to a daily exercise program or to a period of dietary energy restriction (30–50% reduction) before surgery. Researchers will measure tumor and skeletal muscle protein synthesis rates, body composition, muscle strength, and circulating biomarkers such as IGF‑1 using tissue samples collected at surgery and standard clinical tests. The goal is to compare how an exercise-induced energy deficit versus a calorie-restriction-induced deficit affects tumor growth signals and preservation of muscle. Patients receiving pre-operative systemic therapy or those already highly active are excluded to isolate intervention effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with prostate cancer (Stages I-III)
* Scheduled to undergo a prostatectomy
* BMI between 18.5-35 kg/m2

Exclusion Criteria:

* Receiving pre-operative chemo, hormonal, radio therapy
* Physically unable to perform the exercise program
* Performing \>300 min of moderate-vigorous physical activity per week (e.g., running, road cycling, swimming).

Where it's running

• Jessa Ziekenhuis
  Hasselt, Belgium Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Psilocybin-assisted psychotherapy for anxiety after a cancer diagnosis

  This study will test whether psilocybin-assisted psychotherapy using NPX-5 (25 mg or 10 mg versus a low 1 mg dose) helps adults who have anxiety from adjusting to a cancer diagnosis.

  Recruiting at 5 sites Phase 2 Psyence Australia Pty Ltd · Abbotsford, Victoria and 4 other locations · NCT07072728

• Comparing 3D AI-assisted prostate surgery to standard techniques

  This study is testing whether a new 3D robot-assisted prostate surgery can help men with prostate cancer recover better and have fewer complications compared to standard surgery.

  Recruiting at 2 sites Fondazione del Piemonte per l'Oncologia · Candiolo, Turin and 1 other locations · NCT06318559

• Comparing two versus five MRI-guided treatments for prostate cancer

  This study is testing if giving radiation treatment for prostate cancer in just two sessions instead of five can work just as well for men with localized prostate cancer.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT05600400

• Combining a new immunotherapy with radiation for prostate cancer treatment

  This study is testing if a new immune treatment combined with radiation can help men with localized high- and intermediate-risk prostate cancer fight their disease better.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05361798

• Reducing sedentary behavior in prostate cancer survivors

  This study is testing if a special program with support and a FitBit can help prostate cancer survivors move more and sit less over 12 weeks.

  Recruiting University of Toronto · Toronto, Ontario · NCT05214937

• Combining M9241 with Docetaxel for Prostate Cancer Treatment

  This study is testing if the combination of the drug M9241 with docetaxel can help men with advanced prostate cancer live longer and feel better.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04633252

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.