Exercise training for patients with chest pain and no blocked arteries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the causes of chest pain in patients who have no signs of coronary artery blockage, focusing on coronary microvascular dysfunction. It aims to determine whether regular aerobic exercise can improve microvascular function in the heart and other organs, potentially alleviating symptoms. The study is a randomized controlled trial involving 100 patients, who will be assigned to either an exercise training group or a control group. The primary outcome measured will be coronary microvascular function, with secondary outcomes including symptom relief and microvascular function in other tissues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Coronary microvascular dysfunction, defined as myocardial bloodflow reserve (MBFR) \< 2.5 or hyperemic myocar-dial blood flow (hMBF)\<2.3 ml/g/min using \[15O\]H2O-PET
* No obstructive coronary artery disease

Exclusion Criteria:

* Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile
* Heart failure, defined as left ventricular ejection fraction of less than 40%
* Uncontrolled hypertension defined as blood pressure above target 140/90 for all
* Co-morbidity resulting in \<1 year expected survival
* Considered by the investigator, for any reason, to be an un-suitable candidate for the study.
* Unable or unwilling to exercise, e.g. due to arthritis or in-jury\*
* Already are regularly physically active and/or have a maxi-mal oxygen uptake \>45 ml/kg/min

Where it's running

• Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57
  Frederiksberg, Denmark Recruiting
• Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57, Frederiksberg, Denmark, 2000
  Copenhagen, Denmark Not yet recruiting

Study contacts

• Principal investigator: Eva Prescott, MD, DMSc — University of Copenhagen
• Study coordinator: Eva Prescott, MD, DMSc
• Email: Eva.Irene.Bossano.Prescott@regionh.dk
• Phone: 004522572614

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.