Exercise to Improve Sleep in Parkinson's Disease
The Effects of Different Exercise Modalities on Sleep Quality and Architecture in People With Parkinson's Disease
This study tests whether different types of exercise can help people with Parkinson's disease sleep better and improve their overall quality of life.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | McGill University Academic / other |
| Locations | 3 sites (Laval, Quebec and 2 other locations) |
| Trial ID | NCT05644327 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of three types of exercise—cardiovascular, resistance, and a combination of both—on sleep quality and architecture in individuals with Parkinson's disease. Participants will engage in their assigned exercise regimen or a control condition for 12 weeks, with assessments conducted at the start, after the intervention, and at an 8-week follow-up. The study aims to determine if improvements in sleep are linked to enhancements in quality of life aspects such as cognitive and motor function.
Who should consider this trial
Good fit: Ideal candidates are individuals with mild to moderate idiopathic Parkinson's disease experiencing poor sleep quality.
Not a fit: Patients with atypical parkinsonism, severe untreated obstructive sleep apnea, or other significant neurological conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-pharmacological approach to improving sleep quality in patients with Parkinson's disease.
How similar studies have performed: Previous studies have suggested that exercise can improve sleep quality in various populations, indicating potential success for this approach in Parkinson's disease.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn \& Yahr Scale stages 0.5-3.5); * On a stable dosage of medication during the previous month; * Having poor sleep quality defined as a score \> 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality; Exclusion Criteria: * Having atypical parkinsonism, dementia, stroke, or any other neurological condition; * Presenting severe untreated obstructive sleep apnea (OSA); * Having a Montreal Cognitive Assessment (MoCA) score \<18 * Having a Beck Depression Inventory score \>31; * Having absolute contraindications to exercise; * Having severe osteoporosis; * Participating in an exercise or drug trial during the period of the study; * Exceeding the physical activity levels recommended for the general population (≥150 minutes/week of moderate-intensity or ≥75 minutes/week of vigorous-intensity cardiovascular activity) and/or strengthening activities ≥2 days/week.
Where this trial is running
Laval, Quebec and 2 other locations
- Jewish Rehabilitation Hospital — Laval, Quebec, Canada (Recruiting)
- Human Brain Control of Locomotion Laboratory — Montreal, Quebec, Canada (Recruiting)
- Cummings Centre — Montreal, Quebec, Canada (Not_yet_recruiting)
Study contacts
- Principal investigator: Marc Roig, Ph.D. — McGill University
- Study coordinator: Marc Roig, Ph.D.
- Email: marc.roigpull@mcgill.ca
- Phone: 514-398-4400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.