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Clinical trial Recruiting at 1 site Interventional Ages 20 to 80

Exercise to Improve Outcomes in Head and Neck Cancer Patients

Official title: Can Exercise Ameliorate Immunosenescence and Thereby Reduce Relapse in Head and Neck Cancer Patients

Run by Chang Gung Memorial Hospital · NCT06851988 · Data updated 2026-11-12

This study is testing if a specific exercise program can help head and neck cancer patients recover better after surgery and possibly lower their chances of cancer coming back.

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Quick facts

Study typeInterventional
Ages20 Years to 80 Years
SexAll
Enrollment290 (estimated)
SponsorChang Gung Memorial Hospital
Academic / other
Locations1 site (New Taipei City)
StatusRecruiting
StartedMay 3, 2023
Main results expectedOctober 30, 2026
Study endsOctober 30, 2026
Registry record updatedSeptember 24, 2026
Trial IDNCT06851988 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 20 and older diagnosed with squamous cell carcinoma who are undergoing concurrent chemoradiotherapy.

Probably not a fit

Patients with an ECOG performance status of 2 or higher, or those unable to tolerate exercise, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to determine if a safe and effective exercise prescription can help head and neck cancer patients after surgery, particularly focusing on those with oral cancer. The study will explore the relationship between high-intensity interval training (HIIT) and immunosenescence, a condition that may increase cancer recurrence risk. By encouraging regular exercise, the investigators hope to enhance recovery and reduce the likelihood of cancer relapse in these patients. The research will involve monitoring physical activity and assessing its impact on patient outcomes over three years.

Why it matters

Potential benefit: If successful, this study could provide a new approach to improve recovery and reduce cancer recurrence in head and neck cancer patients through exercise.

How similar studies have gone: While exercise interventions have shown success in other cancer populations, the effectiveness in head and neck cancer survivors is still inadequately understood, making this approach somewhat novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age ≥20
2. Pathology:Squamous cell carcinoma
3. Need CCRT treatment
4. ECOG PS\<2
5. Agree with blood drawing, excise training, questionnaire

Exclusion Criteria:

1. ECOG PS≥2
2. Unable to tolerate basic exercise, or CCRT treatment
3. Mental illness or any medical illness or concurrent illness that may be aggravated by exercise training or unmanageable
4. Any medical condition that unsuitable for exercise
5. Disagree to trial procedures: exercise, blood draws, questionnaire

Where it's running

  • TuCheng Hospital
    New Taipei City, Taiwan     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.