Exercise testing using cardiac MRI for patients with severe aortic stenosis
Exercise CMR in (Paradoxical) Low-flow Low-gradient Aortic Stenosis
This study is testing how patients with severe aortic stenosis respond to exercise using advanced heart imaging to help doctors make better treatment choices before they get a heart valve replacement.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Göttingen Academic / other |
| Locations | 1 site (Göttingen) |
| Trial ID | NCT06129799 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates patients with paradoxical or conventional low-flow low-gradient aortic stenosis by conducting physiological exercise-stress cardiac magnetic resonance (CMR) imaging. Participants will undergo CMR assessments in conjunction with standard surveys before undergoing transcatheter aortic valve replacement (TAVR). The goal is to better understand the physiological responses of these patients during exercise to inform treatment decisions.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with paradoxical or conventional severe low-flow low-gradient aortic stenosis.
Not a fit: Patients who are unable to undergo CMR due to device limitations, claustrophobia, or significant renal insufficiency may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the assessment and management of patients with severe aortic stenosis, leading to improved outcomes post-TAVR.
How similar studies have performed: While there is ongoing research in the area of aortic stenosis, this specific approach using exercise-stress CMR is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * paradoxical or conventional severe low-flow low-gradient aortic stenosis Exclusion Criteria: * CMR incapable device * unable to undergo 40 min scan (can not lie flat, claustrophobia) * renal insufficiency (eGFR \<30 ml/min/1.73m²) * allergy against contrast agent * unable to exercise in supine position
Where this trial is running
Göttingen
- University Hospital Goettingen — Göttingen, Germany (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.