Exercise testing using cardiac MRI for patients with severe aortic stenosis
Official title: Exercise CMR in (Paradoxical) Low-flow Low-gradient Aortic Stenosis
Run by University of Göttingen · NCT06129799 · Data updated 2026-11-12
This study is testing how patients with severe aortic stenosis respond to exercise using advanced heart imaging to help doctors make better treatment choices before they get a heart valve replacement.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Göttingen Academic / other |
| Locations | 1 site (Göttingen) |
| Status | Recruiting |
| Started | November 1, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | November 13, 2023 |
| Trial ID | NCT06129799 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with paradoxical or conventional severe low-flow low-gradient aortic stenosis.
✕Probably not a fit
Patients who are unable to undergo CMR due to device limitations, claustrophobia, or significant renal insufficiency may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates patients with paradoxical or conventional low-flow low-gradient aortic stenosis by conducting physiological exercise-stress cardiac magnetic resonance (CMR) imaging. Participants will undergo CMR assessments in conjunction with standard surveys before undergoing transcatheter aortic valve replacement (TAVR). The goal is to better understand the physiological responses of these patients during exercise to inform treatment decisions.
Why it matters
Potential benefit: If successful, this study could enhance the assessment and management of patients with severe aortic stenosis, leading to improved outcomes post-TAVR.
How similar studies have gone: While there is ongoing research in the area of aortic stenosis, this specific approach using exercise-stress CMR is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * paradoxical or conventional severe low-flow low-gradient aortic stenosis Exclusion Criteria: * CMR incapable device * unable to undergo 40 min scan (can not lie flat, claustrophobia) * renal insufficiency (eGFR \<30 ml/min/1.73m²) * allergy against contrast agent * unable to exercise in supine position
Where it's running
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University Hospital Goettingen
Göttingen, Germany Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.