Exercise testing and daily activity in children and adolescents with inherited arrhythmias
Evaluation of Free-living Physical Activity and the Assessment Tools Used to Support Pharmacological Therapy Titration and Exercise Prescription in Children and Adolescents Diagnosed With Inherited Arrhythmias
This study will see if the highest heart rate recorded during a treadmill test matches the peak heart rates kids and teens with inherited arrhythmias reach during their normal daily activity.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 110 (estimated) |
| Ages | 6 Years to 16 Years |
| Sex | All |
| Sponsor | Royal Brompton & Harefield NHS Foundation Trust Academic / other |
| Locations | 2 sites (London and 1 other locations) |
| Trial ID | NCT06661278 on ClinicalTrials.gov |
What this trial studies
This is an observational comparison of peak heart rates from controlled exercise treadmill tests and from two weeks of free-living activity in children aged 6–16 with inherited arrhythmias and their healthy sibling controls. Participants complete a routine exercise tolerance test, then wear a heart-rate and activity monitor for two weeks while keeping a digital diary and finishing a physical activity questionnaire. Investigators will compare maximum heart rates reached on the treadmill with peaks during everyday activity to determine how well the treadmill test reflects real-life exertion and to inform exercise and medication guidance. The study is conducted at Royal Brompton and Great Ormond Street hospitals and includes affected children on beta-blockers or sodium channel blockers and gene-negative sibling controls.
Who should consider this trial
Good fit: Children aged 6–16 years diagnosed with long QT syndrome or catecholaminergic polymorphic ventricular tachycardia who can complete a treadmill test, plus gene-negative siblings aged 6–16 as a healthy comparison group.
Not a fit: Children under 6, adults, those unable to run on a treadmill, non-English speakers (due to lack of translation), and pregnant individuals would not be eligible and would not directly benefit from this protocol.
Why it matters
Potential benefit: If successful, the results could help clinicians set more accurate heart-rate targets for exercise and medication management in children with inherited arrhythmias.
How similar studies have performed: Exercise tolerance testing is well established in adults, but evidence comparing treadmill peak heart rate to free-living activity in children with inherited arrhythmias is limited, so this application is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Affected cohort * Male and female children * Aged 6-16 years * Diagnosed with long QT syndrome or catecholaminergic polymorphic ventricular tachycardia * Treated with beta-blocker and/or sodium channel blockade * Able to complete a treadmill ETT Healthy cohort * Male and female children * Aged 6-16 years * Siblings of affected children (gene negative) * Undergoing IAS screening * Able to complete a treadmill ETT Exclusion Criteria: * Children aged less than 6 years * Adults, 17 years of age and above * Unable to run on an exercise treadmill due to physical limitations. * Individuals unable to speak or understand English, due to no translation service available. * Pregnancy
Where this trial is running
London and 1 other locations
- Great Ormond Street Hospital — London, United Kingdom (Recruiting)
- Royal Brompton Hospital — Sutton, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Catherine E Renwick — Royal Brompton & Harefield NHS Foundation Trust
- Study coordinator: Catherine E Renwick
- Email: c.renwick@rbht.nhs.uk
- Phone: 07968534941
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.