Exercise program for children with sickle cell disease
Low Systemic/High Local Exercise Load in Pediatric Sickle Cell Disease
This study is trying to find out which type of exercise works best for kids aged 12 to 17 with sickle cell disease by comparing a home walking program to a strengthening program over 8 weeks.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 12 Years to 17 Years |
| Sex | All |
| Sponsor | University of Mississippi Medical Center Academic / other |
| Locations | 1 site (Jackson, Mississippi) |
| Trial ID | NCT06387758 on ClinicalTrials.gov |
What this trial studies
This research aims to determine the most effective type of exercise for children aged 12 to 17 with sickle cell disease. Participants will undergo a baseline assessment, including blood tests and questionnaires on pain and emotional health, before being randomized into either a home-based walking or strengthening exercise program for 8 weeks. The program will be conducted via telehealth, with monitoring of physical activity and follow-up assessments to evaluate changes in fitness and well-being. The study will involve a total of 60 families and will last up to 10 weeks for each participant.
Who should consider this trial
Good fit: Ideal candidates are youth aged 12 to 17 diagnosed with specific sickle cell genotypes and have access to the internet.
Not a fit: Patients with cognitive impairments or medical conditions that prevent safe exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve physical fitness and emotional health in children with sickle cell disease.
How similar studies have performed: Other studies have shown positive outcomes with exercise interventions in similar populations, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * youth 12 to 17 years old * diagnosed with SCD genotype SS, SC, beta-plus thalassemia, or beta-zero thalassemia * has daily access to an Internet enabled device (e.g., smart phone, IPad) A parent (≥21 years old) will also be recruited for each youth participant. Exclusion Criteria: * non-English speaking due to lack of available written translation services for informed consent and questionnaires * cognitive impairment (e.g., moderate to profound intellectual disability) that precludes study completion * medical condition (e.g., hypertension, bone fracture) that precludes completing exercise safely (determined by study medical director Dr. McNaull).
Where this trial is running
Jackson, Mississippi
- University of Mississippi Medical Center — Jackson, Mississippi, United States (Recruiting)
Study contacts
- Study coordinator: Cynthia W Karlson, PhD
- Email: ckarlson@umc.edu
- Phone: 6019842723
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.