Exercise program for children with hemophilia
Development Of a haemophiLia PHysiotherapy INtervention for Optimum Musculoskeletal Health in Children (DOLPHIN-II) - a Randomised Controlled Trial
NA · East Kent Hospitals University NHS Foundation Trust · NCT05895032
This study tests whether a special exercise program can help boys aged 6-12 with hemophilia build muscle strength and improve their joint health and activity levels compared to regular care.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 132 (estimated) |
| Ages | 6 Years to 12 Years |
| Sex | Male |
| Sponsor | East Kent Hospitals University NHS Foundation Trust (other gov) |
| Locations | 1 site (Canterbury, Kent) |
| Trial ID | NCT05895032 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effects of a specially designed exercise program aimed at increasing muscle strength in boys aged 6-12 with hemophilia. The study involves a single-blinded, two-arm randomized controlled trial comparing the exercise intervention to usual care over a 12-week period. The goal is to determine whether this exercise can improve joint health, reduce pain, and enhance participation in physical activities. The program was developed with input from children with hemophilia, their parents, and physiotherapists to ensure its relevance and acceptability.
Who should consider this trial
Good fit: Ideal candidates are boys aged 6-12 years diagnosed with severe or moderate hemophilia A or B.
Not a fit: Patients with von Willebrand disease, recent lower limb injuries, or those unable to follow instructions may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the physical health and quality of life for children with hemophilia.
How similar studies have performed: While there is limited robust evidence on this specific approach, preliminary findings suggest that exercise programs can be safe and acceptable for children with hemophilia.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Children aged 6-12 years, with severe or moderate haemophilia A or B Exclusion Criteria: * von Willebrand disease * past history of fracture or trauma to the lower limb * orthopaedic surgery * acquired brain injury or any other disturbance of the central nervous system; joint or muscle bleed in the lower limb in the past 6 weeks * presence of lower limb pain or unable to fully comply with verbal instructions.
Where this trial is running
Canterbury, Kent
- Haemophilia Centre — Canterbury, Kent, United Kingdom (RECRUITING)
Study contacts
- Study coordinator: David Stephensen, PhD
- Email: david.stephensen@nhs.net
- Phone: 01227783166
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hemophilia, Child, Only, Musculoskeletal Diseases or Conditions, Physical Therapy, Exercise, Muscle strength