Exercise effects on blood vesicles and fitness in adults with overweight or obesity
Exploring the Impact of Exercise-derived Extracellular Vesicle in Blood and Physical Fitness Data in Overweight/Obesity Individuals on Lymphangiogenesis
This project will test whether high-intensity interval treadmill exercise changes small particles in the blood (extracellular vesicles) and improves physical fitness in Thai adults aged 25–45 with overweight or obesity.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 25 Years to 45 Years |
| Sex | All |
| Sponsor | Mahidol University Academic / other |
| Locations | 1 site (Mueang Samut Prakan) |
| Trial ID | NCT07312344 on ClinicalTrials.gov |
What this trial studies
This single-center interventional study will enroll Thai adults aged 25–45 with BMI 25–35 who report low physical activity to complete a program of high-intensity interval training on a treadmill. Blood samples will be collected before and after exercise sessions to measure extracellular vesicles and other blood components, and standardized physical fitness tests will track functional changes. Participants will be screened to exclude smokers, people with substance or alcohol addiction, and those with major respiratory or cardiovascular disease. The aim is to link exercise-induced changes in blood markers with measurable fitness improvements to inform prevention strategies, drug development, and health-promotion programs.
Who should consider this trial
Good fit: Ideal candidates are Thai men and women aged 25–45 with BMI 25–35 who lead a sedentary lifestyle and can walk without assistive devices.
Not a fit: People who smoke, have substance or alcohol addiction, have a history of respiratory or cardiovascular disease, or who are outside the specified age or BMI ranges are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the findings could identify blood markers and exercise approaches that help tailor prevention programs or therapies for people with overweight or obesity.
How similar studies have performed: Previous research shows exercise can alter extracellular vesicle profiles and improve fitness in other groups, but applying HIIT with focused EV analysis in overweight Thai adults is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Male or female individuals aged between 25-45 years 2. Thai nationality 3. Ability to walk or perform daily activities independently, without the use of an assistive device 4. Body mass index (BMI) between 25-35 kg/m² 5. Low physical activity levels or sedentary lifestyle based on the World Health Organization 2020 * The levels of moderate-intensity physical activity \< 150-300 minutes per week or the levels of vigorous-intensity physical activity \< 75-150 minutes per week * Moderate-intensity physical activity: fast walking and bicycling. Vigorous-intensity physical activity: running, aerobic dance, and swimming All participants are required to meet all inclusion criteria to be eligible for the research project. Exclusion Criteria: 1. Smoking, substance abuse, or alcohol addiction 2. History of respiratory diseases, such as asthma, emphysema, or chronic obstructive pulmonary disease 3. History of cardiovascular diseases, such as coronary heart disease, aortic disease, arrhythmia, or deep vein thrombosis 4. History of high blood pressure (hypertension) 5. History of vestibular system diseases, such as Meniere's disease or otitis media 6. History of neurological disease, such as severe Parkinson's disease or stroke 7. History of previous lower limb surgery, such as hip, knee, or ankle replacement 8. History of musculoskeletal diseases, such as severe osteoarthritis 9. History of severe brain disease, such as dementia 10. Severe visual or hearing impairment 11. Have a cognitive and comprehensive impairment and unable to complete the intervention 12. Have high physical activity or regularly exercise
Where this trial is running
Mueang Samut Prakan
- Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital — Mueang Samut Prakan, Thailand (Recruiting)
Study contacts
- Study coordinator: Onaong Mee-inta, Ph.D.
- Email: onanong.mee@mahidol.ac.th
- Phone: (66)619922941
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.