Exercise effects on blood vesicles and fitness in adults with overweight or obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center interventional study will enroll Thai adults aged 25–45 with BMI 25–35 who report low physical activity to complete a program of high-intensity interval training on a treadmill. Blood samples will be collected before and after exercise sessions to measure extracellular vesicles and other blood components, and standardized physical fitness tests will track functional changes. Participants will be screened to exclude smokers, people with substance or alcohol addiction, and those with major respiratory or cardiovascular disease. The aim is to link exercise-induced changes in blood markers with measurable fitness improvements to inform prevention strategies, drug development, and health-promotion programs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or female individuals aged between 25-45 years
2. Thai nationality
3. Ability to walk or perform daily activities independently, without the use of an assistive device
4. Body mass index (BMI) between 25-35 kg/m²
5. Low physical activity levels or sedentary lifestyle based on the World Health Organization 2020

   * The levels of moderate-intensity physical activity \< 150-300 minutes per week or the levels of vigorous-intensity physical activity \< 75-150 minutes per week
   * Moderate-intensity physical activity: fast walking and bicycling. Vigorous-intensity physical activity: running, aerobic dance, and swimming All participants are required to meet all inclusion criteria to be eligible for the research project.

Exclusion Criteria:

1. Smoking, substance abuse, or alcohol addiction
2. History of respiratory diseases, such as asthma, emphysema, or chronic obstructive pulmonary disease
3. History of cardiovascular diseases, such as coronary heart disease, aortic disease, arrhythmia, or deep vein thrombosis
4. History of high blood pressure (hypertension)
5. History of vestibular system diseases, such as Meniere's disease or otitis media
6. History of neurological disease, such as severe Parkinson's disease or stroke
7. History of previous lower limb surgery, such as hip, knee, or ankle replacement
8. History of musculoskeletal diseases, such as severe osteoarthritis
9. History of severe brain disease, such as dementia
10. Severe visual or hearing impairment
11. Have a cognitive and comprehensive impairment and unable to complete the intervention
12. Have high physical activity or regularly exercise

Where it's running

• Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital
  Mueang Samut Prakan, Thailand Recruiting

Study contacts

• Study coordinator: Onaong Mee-inta, Ph.D.
• Email: onanong.mee@mahidol.ac.th
• Phone: (66)619922941

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.