Examining the role of the cerebral venous system in stroke patients receiving reperfusion therapy

Study of the Function of Cerebral Venous System in Acute Ischemic Stroke Patients Receiving Reperfusion Therapy

This study is testing how the veins in the brain affect recovery in stroke patients who receive treatment to restore blood flow within 24 hours of their symptoms starting.

Quick facts

• Study type: Observational
• Enrollment: 300 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University (Academic / other)
• Locations: 1 site (Hangzhou, Zhejiang)
• Trial ID: NCT03838289 on ClinicalTrials.gov

What this trial studies

This observational study focuses on patients with acute ischemic stroke who receive reperfusion therapy within 24 hours of symptom onset. Participants undergo neurological examinations and advanced imaging techniques, including multimodal computed tomography and magnetic resonance perfusion, to evaluate various brain parameters. The study aims to investigate the status of the cerebral venous system and its potential impact on patient outcomes following reperfusion therapy. By analyzing venous markers, the researchers hope to identify reliable predictors of prognosis for these patients.

Who should consider this trial

Good fit: Ideal candidates are individuals diagnosed with acute ischemic stroke who can receive reperfusion therapy within 24 hours of onset.

Not a fit: Patients with contraindications to imaging with contrast agents or those unable to provide informed consent may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved prognostic markers for stroke patients, enhancing treatment strategies and outcomes.

How similar studies have performed: While the role of arterial collaterals has been studied, the specific focus on the cerebral venous system in this context is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

1. receive reperfusion therapy within 24 hours after onset;
2. undergo multimodal magnetic resonance computed tomography before reperfusion therapy and CTP or magnetic resonance perfusion at 24 hours after reperfusion therapy;

Exclusion Criteria:

1. Contraindication to imaging with contrast agents;
2. Without provision of informed consent.

Where this trial is running

Hangzhou, Zhejiang

• The second affiliated hosipital of Zhejiang University — Hangzhou, Zhejiang, China (Recruiting)

Study contacts

• Study coordinator: Min Lou, Ph.D

Conditions Stroke; Cerebral Venous System; Reperfusion Injury