Examining the relationship between oral and intestinal bacteria in patients with a specific gum disease
Official title: Characterization of Peroodontal and Intestinal Microbiota in Patients With Gingival Scarring Pemphigoid: a Matched Controlled Study
Run by Centre Hospitalier Universitaire de Nice · NCT06291350 · Data updated 2026-11-12
This study is trying to see how the bacteria in the mouth and gut affect people with a specific gum disease called Mucous Membrane Pemphigoid and whether these bacteria make their gum problems worse.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 3 sites (Nice and 2 other locations) |
| Status | Recruiting |
| Started | October 24, 2024 |
| Main results expected | June 15, 2026 |
| Study ends | November 15, 2026 |
| Registry record updated | March 20, 2025 |
| Trial ID | NCT06291350 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 with MMPg and associated periodontal issues, as well as matched controls with periodontitis or healthy periodontal conditions.
✕Probably not a fit
Patients currently undergoing antibiotic therapy or mechanical periodontal treatment, or those with other chronic immune or digestive illnesses may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the periodontal and intestinal microbiota in patients diagnosed with Mucous Membrane Pemphigoid (MMPg) who also experience desquamative gingivitis. The research aims to understand how the dysbiotic oral microbiota may worsen gingival damage and whether the autoimmune process in MMPg affects the virulence of periodontal pathogens. Participants will undergo plaque sampling, stool collection, and periodontal examinations to assess their conditions and microbiota profiles. The study includes adults over 18 years, focusing on those with varying degrees of periodontal health and MMPg.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of periodontal disease in patients with autoimmune conditions.
How similar studies have gone: While the relationship between oral and intestinal microbiota has been explored, this specific approach in the context of MMPg is relatively novel and not extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults (over 18), non-smokers Arm 1 * MMPg (initial, persistent despite medical treatment, recurrent), periodontitis Arm 2 * non-MMPg, periodontitis, matched to cases on age, gender and severity of periodontitis Arm 3: \- non-MMPg, healthy periodontal conditions, matched to cases on age and gender Exclusion Criteria: * Antibiotic therapy and mechanical periodontal treatment within 3 months prior to study, other chronic general illness of immune or digestive origin
Where it's running
-
Nice University Hospital
Nice, France Recruiting -
Paris hospital Pitié Salpetrière (APHP)
Paris, France Recruiting -
Paris hospital Bretonneau (APHP)
Paris, France Recruiting
Study contacts
- Study coordinator: Sophie DRIDI, PUPH
- Email: dr.sm.dridi@free.fr
- Phone: 04 92 03 30 07
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.