Examining the relationship between oral and intestinal bacteria in patients with a specific gum disease
Characterization of Peroodontal and Intestinal Microbiota in Patients With Gingival Scarring Pemphigoid: a Matched Controlled Study
Centre Hospitalier Universitaire de Nice · NCT06291350
This study is trying to see how the bacteria in the mouth and gut affect people with a specific gum disease called Mucous Membrane Pemphigoid and whether these bacteria make their gum problems worse.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 45 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice (other) |
| Locations | 3 sites (Nice and 2 other locations) |
| Trial ID | NCT06291350 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the periodontal and intestinal microbiota in patients diagnosed with Mucous Membrane Pemphigoid (MMPg) who also experience desquamative gingivitis. The research aims to understand how the dysbiotic oral microbiota may worsen gingival damage and whether the autoimmune process in MMPg affects the virulence of periodontal pathogens. Participants will undergo plaque sampling, stool collection, and periodontal examinations to assess their conditions and microbiota profiles. The study includes adults over 18 years, focusing on those with varying degrees of periodontal health and MMPg.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with MMPg and associated periodontal issues, as well as matched controls with periodontitis or healthy periodontal conditions.
Not a fit: Patients currently undergoing antibiotic therapy or mechanical periodontal treatment, or those with other chronic immune or digestive illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of periodontal disease in patients with autoimmune conditions.
How similar studies have performed: While the relationship between oral and intestinal microbiota has been explored, this specific approach in the context of MMPg is relatively novel and not extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults (over 18), non-smokers Arm 1 * MMPg (initial, persistent despite medical treatment, recurrent), periodontitis Arm 2 * non-MMPg, periodontitis, matched to cases on age, gender and severity of periodontitis Arm 3: \- non-MMPg, healthy periodontal conditions, matched to cases on age and gender Exclusion Criteria: * Antibiotic therapy and mechanical periodontal treatment within 3 months prior to study, other chronic general illness of immune or digestive origin
Where this trial is running
Nice and 2 other locations
- Nice University Hospital — Nice, France (RECRUITING)
- Paris hospital Pitié Salpetrière (APHP) — Paris, France (RECRUITING)
- Paris hospital Bretonneau (APHP) — Paris, France (RECRUITING)
Study contacts
- Study coordinator: Sophie DRIDI, PUPH
- Email: dr.sm.dridi@free.fr
- Phone: 04 92 03 30 07
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pemphigoid, Benign Mucous Membrane, Gingivitis Hyperplastic