Examining the relationship between aging, health, and genetic mutations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the association between various clinical variables related to aging and cardiovascular diseases and mutation status, independent of chronological age. It employs a comprehensive geriatric assessment that evaluates multiple dimensions of health in older adults, including comorbidity, functional status, cognition, and social support. By focusing on these factors, the study aims to provide a more nuanced understanding of aging beyond just age in years.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At least 50 years of age.
* Able to understand written and spoken English.
* Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)

Exclusion Criteria:

* Inability or unwillingness to complete health questionnaire (with the exception of hip and knee replacement participants).
* History of a recent (\<30 days) acute viral illness.
* Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.
* Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.
* Vulnerable populations (e.g. prisoners).
* Known infection with Hepatitis B or C, HTLV, or HIV.
* Additional exclusion for optional bone marrow aspirate/biopsy substudy:

  * Use of medications for anticoagulation or "blood thinning" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)
  * allergy to lidocaine or other local anesthetics.

Where it's running

• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Meagan Jacoby, M.D. — Washington University School of Medicine
• Study coordinator: Meagan Jacoby, M.D.
• Email: mjacoby@wustl.edu
• Phone: 314-747-8439

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.